Multi-modal prognostic biomarkers for Parkinson’s disease progression and severity
Objective: To determine a pathophysiological panel of biomarkers significantly associated with the severity and the disease progression of Parkinson’s disease. Background: Detecting, monitoring and predicting…The overexpression of a-SYN leads to a differential process of mitophagy in neurons and atrocytes
Objective: To determine the role of the different mitophagy pathways involved in PD, a key question that is still unresolved. We will investigate whether a-synuclein…Inhibition of GluN2D-containing NMDA receptors alleviates the loss of dopaminergic neurons and behavioral deficits in 6-OHDA-induced model of Parkinson’s disease
Objective: The aim of this study is to explore whether the inhibition of GluN2D-containing NMDA receptors (NMDAR2D) can delay the pathological manifestations of Parkinson's disease…Antioxidants in foods: A Primary Potential remedy to Neurodegeneration.
Objective: The aim of the research is to establish the plausibility of reducing the effects of the actions of reactive oxygen species, produced by glutamate…Clinical factors associated with neuronal loss in the substantia nigra
Objective: To explore (additional) clinical features associated with nigral neuronal loss that could potentially be included in the criteria for prodromal Parkinson’s disease (PD). Background:…The role of peripheral T- and B-lymphocytes in LRRK2-mediated Parkinson’s disease
Objective: To test the hypothesis the neurodegenerative cascade in the CNS that leads to Parkinson’s disease (PD) is initiated by signals emanating from the peripheral…Relationship between tumor and very slow Parkinson`s disease progression
Objective: We evaluate the Parkinson`s disease patients with very slow progression. One of their clinical features are the medical history of tumor. Background: Some cancer…Plasma membrane Ca2+ Atpase 1 as a candidate to mediate the degeneration of dopaminergic neurons by inflammation in Parkinson’s disease
Objective: To identify genes involved in the degeneration of the dopaminergic neurons (DN) of the substantia nigra (SN) by inflammation. Background: Parkinson’s disease (PD) is…Premature State of Oligodendrocytes Potentially Provides Critical Period for Extracellular Pathological α-Synuclein to Invade Oligodendrocyte Lineage Cells
Objective: Multiple system atrophy (MSA) is pathologically characterized by accumulation of misfolded α-synuclein (α-syn) in oligodendrocytes (OLGs), which is known as glial cytoplasmic inclusions (GCIs).…Characterising the role of alpha-synuclein in ferroptotic programmed cell death in the context of Parkinson’s Disease
Objective: Despite the involvement of alpha synuclein (α-syn) pathology in Parkinson's disease (PD) pathology, the consequences on the neuropathology and the type of programmed cell…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.