Can clinical outputs predict BDNF levels in people with Parkinson’s disease?
Objective: To modelling the relationship between Brain-Derived Neurotrophic Factor (BDNF) levels and clinical variables (stages of disease and cognition) in people with Parkinson's disease (PD).…Object and action naming test in cognitive subtypes in nondemented patients with Parkinson´s disease
Objective: The aim of our study was to identify more homogenous profiles of patients with Parkinson´s disease (PD) without cognitive decline and to compare language…Clinical outcomes after DBS surgery in cognitively impaired patients with PD
Objective: To describe clinical outcomes after DBS in patients with PD and moderate cognitive impairment (CI). Background: DBS is generally contraindicated in PD patients with…Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…Hyposmia as a biomarker in patients with Parkinson’s disease and atypical Parkinsonism
Objective: To investigate neural correlates associated with olfactory dysfunction using fMRI and EEG in Parkinsonism. Background: Patients with Parkinsonism experience non-motor symptoms during the onset…Parkinson’s Disease patients with diplopia exhibit visuospatial and visuoperceptive impairment
Objective: In this study, we investigated Parkinson’s disease (PD) patients with and without diplopia using motor and non-motor assessments, including detailed neuropsychological testing. We hypothesized…SYNGAP1-related intellectual disability with ataxia and late onset of epileptic seizures
Objective: To characterize seizures in a patient with SYNGAP1 mutation and the efficacy of antiepileptic drugs (AEDs). Background: SYNGAP1-related intellectual disability is characterized by developmental…Low Educational Level and Wilson’s disease: A direct path to cognitive decline
Objective: To assess cognitive profile of Wilson's Disease (WD) patients in a single tertiary Movement Disorders center in Fortaleza, Ceará, Brazil. Background: WD is an autosomal recessive disorder…Preclinical pharmacology and early clinical development of dopamine D1 positive allosteric modulators (D1PAMs) with therapeutic potential for neuropsychiatric disorders
Objective: The objective was to characterize novel dopamine D1PAMs pre-clinically in behavioral and neurochemical models and in phase 1 human studies in healthy volunteers and…The dual cognitive syndrome in Parkinson’s disease: volumetric, morphological and tractometric features
Objective: To assess volumetric, morphological and tractometric features associated with the fronto-striatal and posterior cortical cognitive profiles in Parkinson’s Disease (PD) Background: The dual syndrome…
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