Glucocerebrosidase activity and atypical parkinsonism: a multi-centre exploratory study
Objective: We aimed to determine the frequency of Glucocerebrosidase (GBA) deficiency (subclinical Gaucher's Disease type 1, GD1) in patients with atypical parkinsonism (AP) with features…The severity and distribution of tau pathology distinguish corticobasal degeneration and progressive supranuclear palsy
Objective: To elucidate whether the severity and distribution of tau pathology reflect the clinical presentations in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Background:…FDG-PET degeneration patterns predict amyloid deposition in Corticobasal Syndrome
Objective: To investigate if an individual clinically-focused analysis of brain FDG-PET metabolic patterns and a comprehensive neurological evaluation could distinguish Corticobasal Syndrome (CBS) pathological variants…Key neuropathological features separating corticobasal degeneration from other related disorders
Objective: This study investigated the key neuropathological features that could separate corticobasal degeneration (CBD) from related parkinsonian disorders by using a decision tree algorithm. Background:…Initial Validation of the Cortical Basal ganglia Functional Scale (CBFS) in two international, multicenter cohorts: 4RTNI and PROSPECT
Objective: To assess the validity of a patient/caregiver-reported scale for assessing functional disability in 4R tauopathies. Background: 4R tauopathies (4RT) including progressive supranuclear palsy (PSP),…Visuoperceptual impairment: a key feature in the diagnosis of corticobasal degeneration
Objective: We present a patient with a neurodegenerative disease where visuoperceptual testing led to a new working diagnosis of corticobasal degeneration (CBD) Background: CBD is a…Activity of Cerebral Networks, Amyloid and Microglia in Corticobasal Syndrome: the ActiGliA study
Objective: The purpose of this prospective cohort study is to analyse the topographical and temporal relationship between cerebral microglia activity changes, network degeneration and atrophy…Baseline analysis of PROSPECT-M-UK: a longitudinal study of PSP, CBS and MSA
Objective: To complete the baseline analysis of clinical data from the PROSPECT-M-UK study and to assess the impact of applying current MDS PSP diagnostic criteria…Cerebellar involvement in progressive supranuclear palsy and corticobasal degeneration
Objective: To investigate cerebellar involvement in vivo in patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) using [18F]FDG PET. Background: Cerebellar ataxia is…Exploratory Analysis of Electrocortical Signal Complexity in Patients with Progressive Supranuclear Palsy and Corticobasal Degeneration
Objective: We evaluated self-similarity of electrocortical activity as expression of brain signal complexity in patients clinically affected by Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration…
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