Challenging Traditional Paradigm: Clinical Outcomes of Early vs Late Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: Deep brain stimulation(DBS) of subthalamic nucleus(STN) is an established treatment for Parkinson’s disease(PD). DBS has been reserved for patients with long-standing disease and disabling…Single stage Dual target Deep Brain Stimulation for Dystonic Tremor
Objective: Choosing the right target for deep brain stimulation surgery for dystonic tremor can be tricky. Patients usually treated by VIM-DBS or GPi-DBS. Dual targeting is…RESET-DBS: An exploratory study on the safety and efficacy of personalized burst-patterned deep brain stimulation (DBS) in Parkinson’s Disease (PD)
Objective: To assess the safety and efficacy of a personalized burst patterned STN-DBS (bDBS) vs. conventional high-frequency DBS (cDBS). Background: A physiological rationale suggests possible…Bilateral GPi Deep Brain Stimulation for Severe Speech-Induced Dystonic Dysfluency: A Novel Phenotype at the Stuttering-Dystonia Interface
Objective: To report the first case of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) producing transformative improvement in severe speech-induced dystonic dysfluency at…Early-Onset Parkinson’s Disease Is Associated With Higher Utilization of Deep Brain Stimulation: Real-World Data From a Tertiary Movement Disorders Clinic
Objective: To characterize the frequency of early-onset Parkinson’s disease and the use of deep brain stimulation among Parkinson’s disease patients evaluated in a tertiary movement…Modulation of Finely Tuned Gamma in the Globus Pallidus Internus with Deep Brain Stimulation and Levodopa
Objective: To characterize narrow band gamma and finely tuned gamma (FTG) in the globus pallidus internus (GPi) in patients with Parkinson’s disease (PD) and the…Beyond the “best contact”: correlation of ai-guided dbs contact distribution and subthalamic nucleus beta physiology in parkinson’s disease patients
Objective: We hypothesized that optimal stimulation setting may involve a muti-contact configuration rather than a single contact with the largest therapeutic window (TW). We aimed…Clinical Features of DJ1 Gene Mutation Causing Parkinson’s Disease from a Single Centre
Objective: Describe the detailed clinical characteristics of patients diagnosed with Parkinson’s disease (PD) who have the DJ1 gene mutation. Background: Inherited PD represents 5-10% of…Optogenetic mediated inhibition of the subthalamic nucleus alleviates motor symptoms in experimental hemi-parkinsonism mouse model
Objective: Study the potential of optogenetic suppression of STN neurons in alleviating motor symptoms in a PD mouse model using the novel inhibitory opsin eOPN3.…Prediction of Cognitive Decline After STN-DBS in Parkinson’s Disease Using Preoperative Electroencephalography and a Deep Learning Model
Objective: To determine whether preoperative electroencephalography (EEG) combined with deep learning can predict cognitive decline 1 year after subthalamic deep brain stimulation (STN-DBS) in patients…
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