Rescue Electrode Implantation after Deep Brain Stimulation in Parkinson’s disease
Objective: To describe patients with Parkinson’s disease (PD) who underwent a second deep brain stimulation (DBS) surgery with a different target as rescue therapy for…The Use of Digital Tools for Parkinson’s Phenotype Stratification to Improve Patients’ Selection for Advanced Therapies
Objective: Leveraging multimodal patient data to identify distinct multidimensional subtypes of Parkinson’s Disease and improve patient selection for appropriate advanced therapies. Background: The management of Parkinson’s condition is becoming increasingly complex and demanding as the ageing population rises. The NHSE10…Differential effects of levodopa and subthalamic nucleus deep brain stimulation on the bradykinesia components in Parkinson’s Disease
Objective: To quantify and compare the differential effects of DBS and L-dopa on the individual kinematic components of bradykinesia. Background: Parkinson’s disease (PD) bradykinesia is…Delineating Therapeutic and Non-therapeutic Neural Signatures of Deep Brain Stimulation
Objective: To develop an information-theoretic framework that identifies neural signatures predicting therapeutic benefit, independent of stimulation artifacts, enabling objective DBS parameter optimization. Background: DBS programming…Evaluating Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease in the Chinese Population (ADAPT-PD China Study)
Objective: To demonstrate safety and effectiveness of adaptive deep brain stimulation (aDBS) algorithms in participants with Parkinson’s disease (PD) in China. Background: aDBS has been recently…Effect of subthalamic nucleus deep brain stimulation on heart rate variability in Parkinson’s disease
Objective: To characterize the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on cardiac autonomic regulation at rest and during paced deep breathing in advanced…LFP-Based Deep Brain Stimulation Programming and Transition to Adaptive Deep Brain Stimulation in a Patient with Parkinson’s Disease: A Case Report from Thailand
Objective: This case report represents one of the first practical implementations of LFP-guided programming and adaptive DBS in Thailand. Background: Deep brain stimulation (DBS) of…A Retrospective Study Of Outcomes Of Deep Brain Stimulation In Juvenile Parkinson’s Disease.
Objective: To study the clinical characteristics of patients with JPD who have received DBS with their motor and psycho-social outcomes for a maximum of 5…Deep brain stimulation improves levodopa-induced dyskinesias beyond medication reduction in Parkinson’s disease
Objective: To determine whether the improvement in levodopa-induced dyskinesias after deep brain stimulation is primarily associated with reduction in dopaminergic medication or with a direct…Monopolar Sensing within the Globus Pallidus and the Relationship between Clinical Outcomes and Anatomy
Objective: This study aims to understand how results from monopolar sensing of local field potential (LFP) beta power can better support more efficient programming of…
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