Implementing Adaptive Deep Brain Stimulation in Parkinson’s Disease: A Multimodal Mixed-Methods Evaluation of a Pragmatic Clinical Workflow
Objective: The objective of this study is to evaluate a pragmatic clinical workflow and real-world implementation of adaptive Deep Brain Stimulation (aDBS) through integrated clinical,…Simulation Artifact in Complex Deep Brain Stimulation Patients
Objective: To describe stimulation artifacts in patients with complex deep brain stimulation hardware configurations and the impact on electrophysiology recordings. Background: Deep brain stimulation (DBS)…Subthalamic low-frequency activity reflects engagement during live sports viewing
Objective: To investigate subthalamic nucleus (STN) low-frequency dynamics during emotional engagement while watching live sports in patients with Parkinson's disease treated with adaptive deep brain…Reduction in Dopaminergic Medication in Patients with Parkinson’s Disease Treated with Continuous Apomorphine Infusion versus Subthalamic Nucleus Deep Brain Stimulation: A Cohort Study
Objective: To compare the reduction in levodopa equivalent daily dose (LEDD) in patients with Parkinson’s disease treated with continuous subcutaneous apomorphine infusion versus bilateral subthalamic…Video-Based Gait Analysis for Objective Assessment of Motor Severity and Surgical Outcome in Parkinson’s Disease: A Scalable Alternative to Subjective Rating
Objective: To evaluate the accuracy of a gait-focused video analysis model in predicting clinical scores and post-surgical improvement in Parkinson’s disease (PD) Background: The MDS-UPDRS…Prospective International Registry Evaluating Real-World Clinical and Quality-of-Life Outcomes of Directional Deep Brain Stimulation in Essential Tremor
Objective: To assess real-world clinical effectiveness and patient-reported outcomes associated with a multiple independent constant current (MICC) directional deep brain stimulation (DBS) system in individuals…Probable RBD and Anxiety in Early Parkinson’s Disease Predict Subsequent Functionally Disabling Medication-Refractory Tremor
Objective: Functionally disabling, medication-refractory (FDMR) tremor is a key indication for device-aided therapy in Parkinson's disease (PD), yet baseline predictors remain poorly characterised. Background: PD…Experiences with Adaptive Deep Brain Stimulation for Parkinson’s Disease in Routine Clinical Care
Objective: To evaluate initial experiences and (symptom-specific) outcomes with adaptive deep brain stimulation (aDBS) for Parkinson’s disease (PD) in routine clinical care across multiple international…Multi-target Deep Brain Stimulation for Dystonia and Complex tremor syndromes: A Single-Centre Case Series and Literature Review
Objective: This clinical study highlights 10 cases treated at the Walton Centre NHS Foundation Trust (Liverpool, UK) wherein DBS has been implemented beyond unilateral and…Microstructure predicts cognition after Neurostimulation in Parkinson’s disease
Objective: To identify preoperative microstructural markers that are associated with postoperative changes in cognition. Background: Subthalamic deep brain stimulation (STN-DBS) represents an established therapeutic intervention…
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