Key clinical milestones 15 years and onwards after DBS-STN surgery – a retrospective analysis of patients that underwent surgery between 1993 and 2001
Objective: In this paper we investigated patients with advanced Parkinson's disease (PD) operated at our center with subthalamic nucleus deep brain stimulation (STN-DBS) for at…The Cats & Dogs Test: a web-based platform to detect early visual processing deficits in Parkinson’s disease
Objective: To develop a sensitive web-based test to detect visuo-perceptual deficits in patients with Parkinson’s disease as an early marker of dementia. Background: Up to…Structural brain abnormalities associated with preclinical cognitive impairment in Idiopathic Parkinson’s Disease.
Objective: Using the Progressive Parkinson’s Initiative (PPMI) data, clinical and structural differences between individuals destined to develop PD cognitive impairment was defined. Background: Cognitive dysfunction…The battery longevity of implantable pulse generators (IPG) in Parkinson’s disease (PD) is affected by IPG model, number of previous IPG replacements and stimulation energy delivered.
Objective: To determine the effects of stimulation parameters, IPG model and the number of previous IPG replacements on IPG battery longevity. Background: For some patients rechargeable…Predictor of progressive mild cognitive impairment in patients with Parkinson’s disease.
Objective: To clarify clinical features of patients with progressive mild cognitive impairment patients (MCI) in Parkinson’s disease (PD-MCI). Background: Non-demented PD subjects have MCI and…Grey matter abnormalities associated with early cognitive decline in Parkinson’s disease
Objective: To identify patterns of grey matter (GM) abnormalities in patients with Parkinson's disease (PD) with different cognitive profiles. Background: Cognitive symptoms occur already in…How many and which kind of Parkinson’s disease patients need deep brain stimulation surgery? An evaluation based on clinical observation of patients with disease history of 15th year or more
Objective: To grasp real demand of deep brain stimulation (DBS) surgery in a substantial Parkinson's disease (PD) population. Background: DBS surgery has become frequently performed…Genetic risk factors of dementia and psychosis in Parkinson’s disease
Objective: We investigated the impacts of apolipoprotein E (APOE) genotype and glucocerebrosidase gene (GBA) heterozygote mutations on dementia or psychosis in Parkinson's disease (PD). Background:…Olfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson’s disease
Objective: We investigated the pattern of resting state functional connectivity in patients with PD according to olfactory performance to elucidate olfactory-dependent cortical-subcortical functional networks. Background:…Speech prosody impairment predicts cognitive decline in Parkinson’s disease
Objective: We assessed whether baseline speech prosodic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by…
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