Prevalence, Impact, and Suboptimal Treatment of Depression in the Fox Insight Cohort
Objective: Addressing unmet mental health needs in Parkinson’s disease (PD) requires delineating their scope and impact. This study evaluated (1) depressive symptom prevalence and treatment…Comparisons of motor and non-motor features between essential tremor with and without head tremor patiens
Objective: We aimed to explore the motor and non-motor symptoms(NMS) especially cognitive and affective abnormalities of essential tremor (ET) with head tremor (ETh) and those without…Open-Label Study of Pimavanserin Patients With Comorbid Parkinson’s Disease and Depression
Objective: We are assessing use of pimavanserin (PIM) for treatment of depression in adults with PD. Background: Depression occurs in ~50% of Parkinson’s disease (PD)…The effects of zonisamide on motor and non-motor symptoms in patients with Parkinson’s disease: a 3-month open-label study
Objective: To investigate the effect of zonisamide (ZNS) on motor and non-motor symptoms, such as depressive symptoms and sleep problems, in patients with Parkinson’s disease…Higher levels of physical activity is associated with fewer non-motor symptoms in early Parkinson’s disease: a 1-year follow-up study
Objective: To examine the physical activity (PA) level in early Parkinson’s disease (PD) patients and its association with non-motor symptoms (NMS). Background: Lower PA is…Vortioxetine treatment of depression in Parkinson’s disease
Objective: To assess efficacy and safety of Vortioxetine in Parkinson’s Disease (PD) patients affected by depression and its effects on motor performance. Background: Depression is…Impact of a high-fat diet on the behavior of A53T alpha-Synuclein Parkinson’s disease mice
Objective: The aim of this project was to evaluate high-fat diet (HFD) induced behavioral alterations in the A53T alpha-Synuclein Parkinsons’s disease mouse model. Background: Besides…Influence of Cognitive Deficits and Tremor Severity of the Development of Depression in Nondemented Patients with Essential Tremor
Objective: The aim of this study was to investigate the relationship between cognitive deficits and tremor severity with the development of depression in nondemented ET…Neuropsychiatric manifestations in Parkinson’s disease
Objective: Evaluate the different neuropsychiatric manifestations in Parkinson's disease. Background: Parkinson's disease (PD) is the second most common neurodegenerative pathology after Alzheimer's disease, although PD…Pramipexole regulates the depressive-like symptom through dopamine D3 not dopamine D2 receptor in a mouse model of Parkinson’s disease
Objective: The aim of this study is to understand if the antidepressant effect of pramipexole is mediated by D2R or D3R in a mouse model…
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