Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…Translational Target Engagement of HER-096 Demonstrates Concordant Proteostasis and Mitochondrial Modulation in Preclinical Models and Patients with Parkinson’s Disease
Objective: To evaluate translational target engagement of HER-096, a CDNF-derived peptidomimetic, in preclinical models of Parkinson’s disease (PD) and in a Phase 1b clinical study…12-week Aerobic Interval Training Induces Hemisphere-Specific Neuroprotection in Parkinson’s Disease: A Multimodal MRI, [18F]Fluorodopa PET/CT and BDNF Study
Objective: To investigate whether a 12-week aerobic interval training (AIT) can preserve subcortical brain structures in early Parkinson’s disease (PD) and whether these effects are…Modeling Parkinson’s Disease Progression to Quantify Long-Term Treatment Effects via the Concept of ‘Time Saved’
Objective: Evaluate the long-term effectiveness of potential disease-modifying treatments (DMTs) in Parkinson’s disease (PD) using a modelling-based virtual comparator and explore patient-relevant benefits through the…The Emerging Landscape of Genotype-Stratified Clinical Trials in Parkinson’s Disease and Atypical Parkinsonian Disorders
Objective: To characterize the landscape of genotype-stratified clinical trials in Parkinson’s disease (PD) and atypical parkinsonian disorders (APD), including therapeutic targets, geographic representation, and trial…NLRP3 Inhibition in Early-Stage Parkinson’s disease: Results of a Phase Ib Study
Objective: To evaluate the effect of selnoflast, an NLRP3 inhibitor, in persons with early-stage Parkinson’s disease (PD). Background: Damage-associated molecular patterns and pathological alpha-synuclein from damaged or…Exploring a Milestone-Based Approach as an Outcome Measure for Disease-Modifying Parkinson Disease Trials
Objective: To replicate a composite milestone(CM) approach in a range of Parkinson Disease(PD) studies(observational, clinical trials) over a long time period(up to 12 years). To…Assessing an inclusive online lifestyle-based intervention program that supports British Columbians living with chronic neurological conditions, their care partners and healthy agers
Objective: To evaluate the implementation, feasibility, and perceived benefits of the BC Brain Wellness Program (BCBWP), an interdisciplinary lifestyle-based intervention designed to support the quality of…Patient-Defined Disease Progression in Parkinson Disease: Towards Patient-Relevant Outcome Measures
Objective: To carry out a survey on a representative sample of people with Parkinson’s (PwP) about their lived experience of a comprehensive list of Parkinson…Move-Brain-PD: a Randomized Multicenter Protocol of Remotely Monitored Home-based Aerobic Exercise for Parkinson’s Disease Patients with Mild Cognitive Impairment
Objective: To describe the rationale and design of Move-Brain-PD, a randomized multicenter study evaluating whether remotely monitored home-based aerobic exercise improves cognition and motor symptoms…
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