Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study of Ecopipam in Children and Adolescents with Tourette Syndrome
Objective: Evaluate the efficacy and safety of ecopipam in children and adolescents with Tourette’s Syndrome (TS). Background: Ecopipam, a first-in-class selective dopamine-1 (D1) receptor antagonist…Malignant catatonia secondary to clozapine withdrawal: A case report
Objective: To report a patient with malignant catatonia from abrupt clozapine discontinuation. Background: Clozapine blocks 5HT2A/5HT2C serotonin and dopamine receptors. Cholinergic and serotoninergic rebounds have…Long-term safety and activity of ecopipam (ECO), a selective D1 antagonist during treatment of pediatric patients with Tourette Syndrome
Objective: To evaluate the long-term safety and activity of ecopipam (ECO) in the treatment of children and adolescents with Tourette syndrome (TS). Background: D2 antagonists…The association between antipsychotic-induced akathisia and suicidality: a systematic review
Objective: This systematic review aims to establish whether a causal association exists between antipsychotic-induced akathisia and suicidality, in order to guide further clinical decision making…Belly dancer’s dyskinesia due to prochlorperazine
Objective: We aim to present a case report of abdominal wall dyskinesia as a tardive syndrome of prochlorperazine. Background: The clinical presentation of involuntary choreiform…Asymmetrical resting legs tremor induced by levosulpiride
Objective: Our aim is to report unusual case of woman who presented asymmetrical resting tremor of both legs induced by levosulpiride. Background: Resting tremor of…Remote monitoring of physical activity and falls in patients with Huntington’s disease using wearable sensors
Objective: To investigate the use of a novel tele-health system to remotely monitor physical activity and falls in patients with Huntington’s disease. Background: Increased physical…Ecopipam, a selective D1 antagonist in development for the treatment of Tourette syndrome in children and adolescents: The Phase 2b D1AMOND Study
Objective: To describe the Phase 2b study design and optimized dosing strategy to evaluate the efficacy and safety of ecopipam in children and adolescent subjects…The dopamine receptor antagonist haloperidol enhances beta and gamma oscillations and bursts in the motor cortex
Objective: We aimed to investigate the changes in oscillatory activity in the motor cortex (MCtx) and the sensorimotor cortex (SMCtx) of rats after acute injection…Use of Inappropriate Antipsychotics Among US Long-Term Care Residents with Parkinson’s Disease Psychosis
Objective: To characterize the use of inappropriate antipsychotic therapies among residents with Parkinson’s disease psychosis (PDP) in long-term care (LTC) settings in the US. Background:…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.