Distinct effects of apathy and dopamine on effort-based decision making in Parkinson’s disease
Objective: To determine if disrupted effort-based decision making (EBDM) underlies the syndrome of apathy in PD, and whether this disruption is modulated by the dopaminergic…Management of chronic polyneuropathy associated with levodopa-carbidopa intestinal gel infusion in Parkinson’s disease: Review of the strategies and perspectives
Objective: (1) To make an inventory of the current strategies used to treat or prevent the occurrence of chronic polyneuropathy (CPN) in patients with Parkinson’s…The Effect of Sleep Deprivation on Short-Term Memory and Emotion of Rotenone Treated Zebrafish Model of Parkinson Disease
Objective: We investigated the long-term consequences of sleep deprivation on short-term memory and emotion using a rotenone treated zebrafish model of Parkinson disease. Background: Parkinson…Impact of STN-DBS on Medication Reduction
Objective: We aim to evaluate the efficacy of subthalamic nucleus deep brain stimulation on reducing medication in Parkinson´s disease patients. Background: Parkinson's disease (PD) is…Off-painfull state in Parkinson’s disease patients: A redflag of complulsive behavior. Data from a PET-FDG study
Objective: The aim of this study was to investigate the neural underpinnings of the dopaminergic dysregulation syndrome( DDS ) during the “off-phase”. Background: The DDS…Striatum of the ouabain-induced pharmacological DYT12 mouse model is affected by structural and metabolic abnormalities
Objective: To study changes in neuronal morphology and neurotransmitter metabolism in the striatum of a pharmacological DYT12 mouse model after induction of a dystonic phenotype…No differences in the total burden of non-motor symptoms between Parkinson’s disease and non-degenerative parkinsonism
Objective: To compare the total burden of non-motor symptoms between Parkinson's disease and non-degenerative parkinsonism and to study the possible dopaminergic background of these symptoms.…Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences
Objective: Assess the correlates of movement vigor in Substantia Nigra dopaminergic neurons Background: Current basal ganglia models have focused on the role of dopamine in…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…Parkinson’s disease disrupts motor skill learning that requires improvement of a speed-accuracy trade-off
Objective: 1) To test whether PD reduces the ability to improve motor acuity (speed-accuracy trade-off performance) in goal-directed movements; 2) To examine the effect of…
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