Effects of a next-generation neurotrophic compound in a toxin model of Parkinson’s disease
Objective: Investigate the effects of a peripherally administered novel neurotrophic compound, CMx01a, in 6-hydroxydopamine rat model of Parkinson’s disease. Background: Neurotrophic factors are promising drug…Distribution of intranasal hNSCs in a mouse model of MPTP-induced Parkinson’s disease
Objective: We aimed to map the distribution of human neural stem cells (hNSCs) in the brain and peripheral tissues after intranasal administration in a mouse…Bioengineered nigrostriatal constructs model Lewy pathology
Objective: To better understand Parkinson’s disease (PD) pathophysiology and enhance therapeutic development by bioengineering an in vitro nigrostriatal system that mimics the complex architecture of…Sequencing of single human nigral dopaminergic neurons for somatic copy number variants
Objective: To detect somatic DNA copy number variants (CNVs) in dopaminergic neurons isolated from human substantia nigra, using shallow whole genome sequencing (WGS). Background: Somatic…No link between striatal dopaminergic axons and dopamine transporter imaging in Parkinson’s disease
Objective: The objective of this study was to investigate if dopamine transporter (DAT) binding is associated with dopaminergic neurites in the putamen. Background: Dopamine transporter…HGprt deficient brain RNA expression patterns reveal specific abnormalities related to neuronal function in a mouse model of Lesch-Nyhan disease.
Objective: To determine the effect of hypoxanthine guanine phosphoribosyl transferase (HGprt) deficiency on mouse brain RNA expression patterns in multiple brain areas, during embryonic development…Differentiating the substantia nigra pars compacta and ventral tegmental area in early-stage Parkinson’s disease using quantitative susceptibility mapping
Objective: To assess iron levels in dopaminergic midbrain nuclei using quantitative susceptibility mapping for identification of biomarkers of PD. Background: The midbrain dopaminergic system plays…HGprt deficiency affects early brain development in vivo in a mouse model of Lesch-Nyhan disease
Objective: To determine the effects of hypoxanthine guanine phosphoribosyl transferase (HGprt) deficiency on early brain development in vivo, in a HPRT1-deficient mouse model. Background: Lesch-Nyhan…The Role of Dysfunctional BDNF in Remodeling the Parkinsonian Striatum Following Dopamine Neuron Grafting in CRISPR rs6265 Rats
Objective: To evaluate the impact of the rs6265 Bdnf single nucleotide polymorphism (SNP) on function & synaptic integration of primary dopamine (DA) neuron grafts in…Differential effects of stem cell therapy in adult and middle-aged Parkinsonian mice
Objective: To perform an in-depth analysis of the effects of transplanting neural stems cells in Parkinsonian mice. Background: Parkinson´s disease (PD) is the second most…
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