Levodopa-induced orthostatic hypotension in parkinsonism: a red flag of autonomic failure
Objective: To evaluate the cardiovascular and hemodynamic effect of LD in patients with parkinsonism on chronic LD treatment. Background: Levodopa (LD) is the main treatment…Observations on 5 Parkinson’s patients taking Mucuna pruriens as natural source of levodopa
Objective: To explore potential benefits and tolerability of extracts from Mucuna pruriens for dopaminergic treatment of Parkinson’s patients. Background: Capsules containing freeze-dried, aqueous extract from…The effect of dopaminergic medication on force fluctuation in Parkinson’s disease
Objective: To quantify and compare muscle force variability during isometric dorsiflexion in male patients with Parkinson's Disease (PD), in the ON- versus OFF-medication state. Background:…Does the dopaminergic pathway interfere with the sustained CSF tap test effect in normal-pressure hydrocephalus?
Objective: To discuss the possible dopaminergic pathway interference as a mechanism underlying the sustained benefit of the CSF tap test in NPH. Background: The sustained…Protective approach targeting NF-kB/ Nrf2 signaling and neuroinflammation using Apigenin in LPS induced Parkinsonism in experimental rats
Objective: 1. Apigenin as a protective strategy to prevent neuroinflammation in PD.2. To find behavioral, neurochemical and histopathological changes in LPS induced PD. Background: Parkinson’s…Gold and silver nanoparticle-based Localized Surface Plasmon Resonance Sensor (LSPR) for the detection of histidine as a potential biomarker in Parkinson’s Disease.
Objective: Previous literature has proven that histamine has a crucial role in the process of neuroinflammation in Parkinson's Disease (PD) . We can indirectly detect…Patient-Reported Impact of Standard-of-Care: Change in Symptoms Following Dopamine Initiation and Deep Brain Stimulation
Objective: The goal of this study was to describe changes in patient-reported symptoms following initiation of standard-of-care treatment strategies in Parkinson’s disease (PD). Background: A…IMPACT OF STANDARD-OF-CARE MEDICATIONS ON TIME-OFF READOUTS IN CLINICAL TRIALS. A QUANTITATIVE SYSTEMS PHARMACOLOGY APPROACH
Objective: To mitigate clinical variability of Time-Off with various therapeutic combinations Background: There is increasing interest to use wearable-based digital health measures to continuously monitor…Comparison of Antiparkinsonian Medication Initiation and Levodopa-Equivalent Daily Dose Across PPMI, STEADY-PD III, and SURE-PD3
Objective: To compare use of antiparkinsonian medications (APM) among early Parkinson disease (PD) patients across clinical study cohorts. Background: Initiation of APM is a key…The course of tremor in de novo PD: 7 year longitudinal analysis
Objective: To longitudinally describe the course and clinical characteristics of tremor in Parkinson Disease (PD) over a seven-year follow up. Background: Tremor is a cardinal…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.