A Large-Scale Digital Parkinson Disease Platform Matches Clinician Identification of Dyskinesia and Uncovers Unmet Need Between Visits
Objective: To evaluate whether continuous remote monitoring can identify dyskinesia at scale, detect between-visit worsening, and support more efficient patient-clinician communication about management. Background: Dyskinesia…Levodopa-Induced Dyskinesias in Patients with Parkinson’s Disease in the Uzbek Population
Objective: To investigate the clinical features and prevalence of levodopa-induced dyskinesias in patients with Parkinson’s disease in the Uzbek population. Background: Levodopa-induced dyskinesias (LID) are…Functional Belly Dancer Dyskinesia Associated with Abdominal Pain: A Case Series
Objective: To describe belly dancer dyskinesia (BDD) presenting as a manifestation of functional movement disorder associated with abdominal pain, and to emphasize the role of…Caffeine and Tobacco Exposure and the Presence of Levodopa-Induced Dyskinesia (LID) in the STAT-PD Trial
Objective: Using data from the STAT-PD trial, ClinicalTrials NCT # 4064294, we examined whether lifetime caffeine and nicotine exposure are associated with the presence and…Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia
Objective: To determine whether chronic IEM-1460 administration alters dyskinesia and perineuronal net (PNN)–parvalbumin interneuron (PV-IN) association in a 6-OHDA rat model of L-DOPA-induced dyskinesia (LID).…When Presynaptic Stimulation is Not Enough: Severe Biphasic Dyskinesia on LECIG Reversed by Postsynaptic Apomorphine Rescue
Objective: To report an exceptional case of advanced Parkinson’s disease (PD) where levodopa/carbidopa/entacapone intestinal gel (LECIG) failed to provide adequate motor control, ultimately requiring a…Subthalamic Beta Sub-band Composition and Gamma Dynamics Across Medication and Stimulation States in Parkinson’s Disease
Objective: To examine how levodopa pharmacodynamics and therapeutic deep brain stimulation (DBS) shape beta sub-band composition and gamma oscillations in the subthalamic nucleus (STN), and…Levodopa-Carbidopa Intestinal Gel Infusion Therapy in Advanced Parkinson’s Disease: Extension Study of Long-term outcomes of Single Centre experience
Objective: evaluate the long-term outcomes of levodopa-carbidopa intestinal gel (LCIG) infusion in patients with advanced PD with motor fluctuation in one centre Background: Levodopa-carbidopa intestinal…Beta–motor state correspondence as a predictor of adaptive deep brain stimulation benefit in Parkinson’s disease
Objective: To clarify practical factors for optimizing adaptive deep brain stimulation (aDBS) to achieve better clinical outcomes in Parkinson’s disease (PD). Background: aDBS is a…Safer AI Dosing Recommendations in Parkinson’s Disease Through Uncertainty-Adaptive Prediction
Objective: To develop and validate a uncertainty-adaptive AI framework to improve the safety and clinical utility of levodopa dose predictions by explicitly flagging high-risk, ambiguous cases…
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