Levodopa-Induced Dyskinesia Predicts Falls, Fall-Related Injuries, and Their Consequences in Parkinson’s Disease: A Prospective PPMI Cohort Study
Objective: This study aimed to (i) assess the prevalence and incidence of falls, (ii) identify contributors to falls, and (iii) examine injuries and consequences caused…Impact of Multi-day Wearable Monitoring on Neurologists’ Assessment of Motor Fluctuations and Treatment Strategies in Parkinson’s Disease: A Real-World Study
Objective: To assess the impact of wearable-device objective metrics on neurologists’ perception and therapeutic decisions in a real-world cohort of patients with Parkinson’s disease (PD).…Progressive Lifelong Chorea with Spastic Paraparese and Cerebellar Ataxia Associated with Two Heterozygous Variants in the SYNE1 Gene: A Case Report
Objective: To report a case harboring two different heterozygousSYNE1 variants whose combined effect is suspected tounderlie a complex neurogenetic phenotype Background: SYNE1 encodes nesprin-1, one…Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion in Advanced Parkinson’s Disease: Results from a Prospective Real-world Study
Objective: To evaluate the effectiveness and tolerability of continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) infusion in patients with advanced Parkinson’s disease (PD) in a real-world setting. Background: In…Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia
Objective: Chronic treatment of L-DOPA causes dyskinesia (LID) in PD patients. We aim to understand LID from a lipid-metabolism perspective and identify novel therapeutic targets.…Unmasking the Masquerader: Paroxysmal Kinesigenic Dyskinesia (PKD) Misdiagnosed as Epilepsy for Nearly a decade: Time to Act (Consecutive Cohort of 25 patients)
Objective: To characterize the clinical phenotype, diagnostic journey and one year treatment outcomes in paroxysmal kinesigenic dyskinesia (PKD) at a tertiary movement disorder centre in…High Step Marching Dyskinesia: A Case Series
Objective: To describe high step marching dyskinesia in two patients with Parkinson's disease (PD) Background: Levodopa-induced dyskinesias can interfere with gait in patients with Parkinson’s…Sleep Disturbances and Dyskinesia Burden in Parkinson’s Disease: Relevance for Motor Complication Management
Objective: To examine if dyskinesia severity, assessed both clinically and using wearable technology, is independently associated with global and domain-specific sleep disturbance in people with…External Validation of Reported Clinical Predictors of Levodopa-Related Adverse Drug Reactions in Parkinson’s Disease
Objective: To assess the predictive value of previously reported clinical and demographic predictors for levodopa-related adverse drug reactions in the Dutch multicenter Profiling Parkinson’s disease…Unveiling the unusual: PNMA2 paraneoplastic syndrome
Objective: To present a rare case report Background: A 69 year old woman presented with progressive ptosis, change in voice (hypophonia), dysphagia, generalised weakness with…
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