Modulation of working memory in prodromal DLB by non-invasive brain stimulation of the striatum and cerebellum
Objective: We aimed to modulate working memory (WM) in patients with MCI with Lewy bodies (MCI-LB) by non-invasive stimulation of the striatum with or without…Repeated Scanning Ultrasound in an Alpha-synuclein Preformed Fibril model
Objective: To investigate the therapeutic potential of repeated scanning ultrasound (SUS)-mediated blood-brain barrier (BBB) opening in a mouse model of Parkinson’s disease (PD). Background: PD…Impact of Gastrointestinal Dysfunction Symptoms on Psychomotor Recovery Following 8-Week Aerobic Interval Training in Parkinson’s Disease – Preliminary Results
Objective: To investigate the impact of gastrointestinal dysfunction symptoms (GIDS) on psychomotor recovery following 8-week aerobic interval training (AIT) in Parkinson's disease (PD). Background: GIDS…Honey products in Parkinson’s disease – randomized placebo-controlled double-blind pilot study
Objective: The purpose of this study is to examine whether consumption of honey products can improve symptoms and their diurnal fluctuations in patients with Parkinson's…Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of Vent-02, a Novel CNS-Penetrant NLRP3 Inhibitor for the Treatment of Parkinson’s Disease
Objective: The objectives of this first-in-human study were to assess the safety, tolerability, pharmacokinetics (PK), food-effect and pharmacodynamics of VENT-02 in healthy volunteers Background: Vent-02…Retention & Safety in a Home-Based Fracture Prevention Trial of Zoledronate vs Placebo (TOPAZ) in Persons with Neurodegenerative Parkinsonism (NDP)
Objective: To assess retention and safety in the ongoing TOPAZ trial, NCT03924414 Background: People with NDP face a four-fold increased fracture risk, yet preventive treatment…Solengepras: An Investigational Therapy with Potential Benefits on Functional and Non-Motor Measures in Parkinson’s Disease (PD)
Objective: Solengepras is a GPR6-inhibitor that is being studied as an investigational treatment for Parkinson’s Disease (PD). Background: GPR6 is a novel G-protein-coupled receptor found…Impact of Allogeneic Mesenchymal Stem Cells in Motor and Non-Motor Symptoms of Parkinson’s Disease: A Phase 2 Randomized Trial
Objective: To assess the efficacy of repeated intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions in reducing motor and non-motor symptoms in people…Impact of Over-the-counter Cannabidiol Products on Cognition During the Course of Parkinson’s Disease
Objective: To evaluate the association between Cannabidiol (CBD) usage and cognitive performance, measured by The Montreal Cognitive Assessment (MoCA) in people living with Parkinson's Disease…Fecal Microbiota Transplantation for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess Fecal Microbiota Transplantation (FMT) efficacy in improving Parkinson’s disease (PD) symptoms. Background: Dysregulation of the microbiome–gut–brain axis is a key pathophysiological mechanism…
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