mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…The mGlu2 positive allosteric modulator BINA extends enhances low dose L-DOPA anti-parkinsonian action in the MPTP-lesioned marmoset
Objective: To determine the effect of positive allosteric modulation of the metabotropic glutamate type 2 (mGlu2) receptor in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset using a low…Administration of the mGlu2 positive allosteric modulator BINA as monotherapy improves parkinsonism in the MPTP-lesioned marmoset
Objective: To assess the effect of selective metabotropic glutamate type 2 (mGlu2) receptor activation on parkinsonism as monotherapy in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset compared to…Mutational effects of LRRK2 I1371V in astrocytes derived from patient specific iPSCs
Objective: To identify the LRRK2 I1371V mutational effects on astroglial biology involving glutamate metabolism and glutathione machinery. Background: The underlying cause of most of the familial…Antioxidants in foods: A Primary Potential remedy to Neurodegeneration.
Objective: The aim of the research is to establish the plausibility of reducing the effects of the actions of reactive oxygen species, produced by glutamate…Induction of Parkinsonian-like changes via targeted down-regulation of astrocytic glutamate transporter GLT-1 in the striatum
Objective: The aim was to explore the function and mechanism of astrocytic GLT-1 in PD-like changes. Background: Numerous researches suggest decreased expression of glutamate transporter-1…Long-term effect of safinamide on primary motor cortex excitability and plasticity in Parkinson’s disease: a TMS study
Objective: To examine the long-term effect of chronic treatment with safinamide 100 mg/day on specific Transcranial Magnetic Stimulation (TMS) measures of primary motor cortex (M1)…Neuroprotective effects of allicin microemulsion against intrastriatal rotenone and manganese induced Parkinsonism in rats
Objective: Allicin is flavonoid that possess neuroprotective potential but main impediment is its low bioavailability which was improved with microemulsion. The present study was framed…Type-3 Metabotropic Glutamate Receptors and Parkinson’s Disease: Preclinical Studies and Human Genetics
Objective: In a MPTP mice model of toxicological parkinsonism we examine whether the presence or absence of mGlu3 receptors is neuroprotective. We also evaluted association…Increased availability of the metabotropic glutamate receptor 5 in the motor system of patients with Parkinson’s disease
Objective: To investigate glutamatergic signaling in Parkinson’s disease (PD) compared to age- and gender-matched healthy controls by using 11C-ABP688-PET combined with MRI. Background: Increasing evidence…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.