The highly-selective metabotropic glutamate receptor 2 positive allosteric modulator LY-487,379 alleviates psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
Objective: To investigate the effect of metabotropic glutamate receptor 2 (mGluR2) activation on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced psychosis-like behaviours (PLBs) and dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset…Patient-reported hallucinations and the probability of progression to dementia in Parkinson’s disease
Objective: To evaluate the influence of neuropsychiatric symptoms in identifying Parkinson’s disease (PD) patients who will progress to dementia (PDD) in the imminent future (~4…Defective visual perception in patients with Lewy body disease: assessment of hallucinations with pareidolia test.
Objective: Hallucination is a common feature in patients with advanced Parkinson’s disease(PD) and dementia with Lewy bodies (DLB). Background: The pareidolia test is a tool…Systematic Evaluation of Major and Minor Psychotic Symptoms in Parkinson’s Disease
Objective: To evaluate a structured clinical interview (SCI) based on the Parkinson’s disease-specific Scale for the Assessment of Positive Symptoms (SAPS-PD) in the identification of…Predictors of onset of psychosis in Parkinson’s disease: “Who gets it early?”
Objective: To explore the factors which may predict the onset of psychosis in Parkinson’s disease (PD). Background: Non-motor symptoms (NMS) are commonly observed in PD.…Treatment of Psychosis in Parkinson’s Disease: Evidence-Based Recommendations Versus Actual Clinical Practice
Objective: To examine if actual clinical practice of antipsychotic use in Parkinson's Disease patients are consistent with published evidence-based reviews of treatment recommendations and discuss…Minor hallucinations in Parkinson’s disease: neuropshycological and neurophysiological correlates in a representative sample of non-demented patients.
Objective: To study the neuropsychological and neurophysiological correlates of minor hallucinations (mH) in non-demented PD patients, by using different scales and the event-related potentials (ERP)…What do patients with Parkinson’s disease see in their hallucinations? Classification of hallucinations which are seen in Parkinson’s Disease; Single Center Experience
Objective: Our purpose is to evaluate and classify visiual hallucination of 52 patients with Parkinson' s Disease and to detect if there is any relation between…A Phase 2 Study of Nelotanserin, a Novel 5HT2A Receptor Inverse Agonist, in Dementia with Lewy Bodies and Parkinson’s Disease Dementia Subjects Experiencing Visual Hallucinations
Objective: To evaluate the safety and efficacy of nelotanserin in Lewy body dementia subjects experiencing visual hallucinations. Background: Nelotanserin is a selective 5HT2A receptor inverse…Aberrant resting state functional brain networks in patients with Parkinson’s disease and visual hallucinations
Objective: To explore the neural correlates of Visual Hallucinations (VH) in patients with Parkinson’s disease (PD). Background: Psychosis is one of the commonly observed non-motor…
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