Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Alteration of peripheral blood cell profiles in Parkinson’s disease: a retrospective case-control study
Objective: The aim of this study is to investigate the relationship between peripheral blood cell profiles and Parkinson's disease (PD). Background: Abnormal immune response and systemic inflammation have…Impact of Th17 pathway-related immuno-inflammatory cytokines in the risk and severity of Parkinson’s Disease.
Objective: To delineate the impact of T helper 17 (Th17) pathway-related cytokines in the risk, severity and psychopathology of patients with Parkinson’s Disease (PD). Background:…mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…Parkin deficiency impairs mtDNA dynamics and propagates inflammation
Objective: We sought to explore Parkin’s role in (i) averting neuronal mtDNA dyshomeostasis/release and (ii) the activation of downstream inflammatory processes. Background: Mutations in Parkin…Safety and Tolerability of a Ketone Supplement in Parkinson’s Disease
Objective: To investigate the safety and tolerability of a high-dose exogenous ketone supplement in people with Parkinson’s Disease (PD). Background: Animal models and small pilot…Role of S100B in the Pathogenesis of Parkinson’s Disease
Objective: This review aims to analyze studies on the implication of S100B in Parkinson's Disease (PD) and shed light on Pentamidine as a novel treatment in…Effect of Ketone Ester Supplementation on Motor and Non-Motor symptoms in Parkinson’s Disease
Objective: To investigate the effect of exogenous ketone ester supplementation on motor and non-motor symptoms in Parkinson’s Disease (PD). Background: Animal research and human pilot…Peripheral immune profile and neutrophil-to-lymphocyte ratio in Parkinson’s disease
Objective: The present study aimed to determine whether a different peripheral immune profile and neutrophil-to-lymphocyte ratio were present in Parkinson’s disease (PD) patients compared with…The pandemic stress impact on disease progression in COVID-19 seronegative patients with idiopathic Parkinson’s Disease.
Objective: To investigate the impact of chronic stress (CS) induced by the present pandemic on the progression rates of motor and cognitive impairment, on neuro-inflammatory…
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