Interventions in Friedreich’s Ataxia and their Influence on Patient-centric Outcomes: A Systematic Review
Objective: The presented systematic review summarizes available pharmacological and non‑pharmacological interventions for patients with Friedreich's ataxia, their outcomes, and alignment with patient‑centered health domains as…The Therapeutic Landscape of SSPE: A Systematic Review of Antiviral and Immunomodulatory Modalities
Objective: To systematically map the global therapeutic landscape of SSPE interventions, specifically characterizing drug regimens, dosages, administration routes, and monotherapy versus combination protocols. Background: SSPE…Digital cognitive training and promoting a healthy lifestyle as a booster for cognitive reserve in prodromal Parkinson’s disease?
Objective: To investigate predictors of responsiveness to a multimodal cognitive training intervention in individuals with isolated REM sleep behavior disorder (iRBD). Background: The prodromal phase…Slow-SPEED-US: Initiation of a Remote Exercise Trial in LRRK2 and GBA1 Carriers
Objective: To describe the launch of Slow-SPEED-US, presenting recruitment results and baseline characteristics of the enrolled subsample. Background: Slow-SPEED-US is part of a network of…EAGLE: Protocol for a Phase 3 Study to Evaluate the Efficacy and Safety of Two Mobile Applications Combined with Immediate-Release CD/LD for the Management of Idiopathic Parkinson’s Disease
Objective: To evaluate the efficacy and safety of Hybridopa A and Hybridopa B, combination products of immediate-release carbidopa/levodopa (IR CD/LD) and therapeutic mobile applications, in adults with idiopathic Parkinson’s disease (PD) on a…The Effects of Bright Light Therapy on Improving Sleep Disorders in Parkinson’s Disease
Objective: To explore the effects of bright light therapy (BLT) on improving sleep disorders in Parkinson‘s disease (PD). Background: Sleep disorders are common clinical symptoms…Barriers and Enablers to Diversity and Inclusion in Movement Disorders Research (BIND-MD)
Objective: BIND-MD aims to identify barriers that hinder participation of ethnic minorities in movement disorders research, examine sources of mistrust and develop strategies to overcome…Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial of a Remote Gamified Physical Activity Programme in Adults with Hyposmia
Objective: To evaluate the feasibility, adherence, acceptability, and safety of a long-term, fully remote, gamified physical activity intervention in adults with objectively confirmed hyposmia, and…ALPHA-FIT: Slowing cognitive decline in alpha-synucleinopathies by enhancing physical activity
Objective: To evaluate the effects of increased physical activity on cognitive decline in patients with isolated REM sleep behavior disorder (iRBD). Background: Physical activity has…Impact of Hula on Balance Outcomes in Parkinson’s Disease
Objective: This study aims to determine the impact of a 12-week Hula program on balance in patients with Parkinson’s Disease (PD) and to investigate changes…
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