Ferritin-related Brain Iron Deposition in Parkinson’s Disease Involves α-Synuclein Pathology
Objective: To investigate plasma neuron-derived ferritin-containing extracellular vesicles (NDFEVs) differences between Parkinson’s disease (PD) patients and controls, assess their association with brain iron deposition, and explore the…Deferiprone improves striatal dopamine by reducing neuroinflammation and oxidative stress in MPTP-induced mice model of Parkinson’s disease
Objective: This study aimed to investigate the effect of deferiprone on the striatal DA, oxidative stress and neuroinflammation markers as well as motor deficits in…Brain De-Ironization with Nasal Spray of Iron Chelator in Treatment of Multiple System Atrophy, a Case Trial
Objective: Iron removal seems to be a treatment approach in Multiple system atrophy (MSA) because pathological findings shows the accumulation of iron and α-synuclein protein…Effects of ATH434, a Clinical-Phase Small Molecule with Moderate Affinity for Iron, in a Parkinson’s Disease Model in Macaques
Objective: (1) Determine whether oral ATH434 improves motor performance in a non-human primate hemiparkinasonian model when administered after symptom onset. (2) Relate observations to changes…Serum Alpha-Synuclein Levels Are Decreased in Patients with Restless Legs Syndrome and Restored by Intravenous Iron Therapy in Correlation with Ferritin
Objective: To determine potential connection between serum Alpha-synuclein (α-syn) concentrations and restless legs syndrome (RLS), and explore the impact of intravenous (IV) iron supplementation on serum…Neurodegeneration with brain iron accumulation in pediatric population: Clinico-radiologic and genetic features
Objective: To correlate, clinical and magnetic resonance imaging (MRI) characteristics with genetics, of pediatric patients with Neurodegeneration with brain iron accumulation (NBIA). Background: NBIA is…Unraveling the Complexity of Neurodegenerative Disorders: A Case Report of PKAN Suspected in a 24-Year-Old Patient with Severe Dystonia
Objective: To present a case study of a 24-year-old patient with severe dystonia and cognitive decline, suspected to have Pantothenate Kinase-Associated Neurodegeneration (PKAN), a rare subtype…Huntingtonism and bilateral basal ganglia hypointensity in a male with an XK variant but no McLeod red cell phenotype
Objective: To report a novel variant of XK without the characteristic RBC phenotype Background: XK disease (previously called McLeod Syndrome) is a rare X-linked disorder…Distinct deep grey matter iron accumulation in tremoric syndromes; an apparent quantitative susceptibility mapping mangetic resonance study
Objective: To investigate regional iron accumulation in patients with essential tremor (ET) and Parkinson´s disease (PD) and its clinical associations with apparent susceptibility-weighted imaging (SWI)…Consideration of age and initial putaminal rim segment in distinguishing multiple system atrophy parkinsonian type
Objective: To improve diagnostic performance in distinguishing multiple system atrophy parkinsonian type (MSA-p), we investigated the iron deposition pattern in the putaminal lateral margin of…
- 1
- 2
- 3
- …
- 6
- Next Page »