Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression
Objective: To characterize disease heterogeneity and how sex impacts motor and cognitive progression class membership across genetic subgroups of GBA1, LRRK2, and idiopathic Parkinson disease (PD). Background: Autosomal…Monocyte and T-cell Immunological Profiles of Asian LRRK2 Variants G2385R And R1628P in Parkinson’s Disease: Associations with Clinical Measures
Objective: To evaluate the clinical correlates of monocyte and T-cell immunoprofiles in Parkinson’s disease (PD) with and without Asian LRRK2 variants. Background: Immune dysregulation has…Genomic Insights into Parkinson’s Disease: LARGE-PD and PD GENEration Collaboration in El Salvador
Objective: To characterize clinical and genetic features of Parkinson’s disease (PD) in El Salvador in the PD GENEration and LARGE-PD. Background: Central American populations remain…Urine and Plasma Bis(monoacylglycero)phosphate (BMP) in Asian LRRK2 p.G2385R and p.R1628P Variant Carriers with Parkinson’s Disease
Objective: To compare urine and plasma bis(monoacylglycero)phosphate (BMP) levels in Parkinson disease (PD) patients carrying Asian-prevalent LRRK2 variants (p.G2385R, p.R1628P) against idiopathic PD (iPD) and…Genetic analysis of Mongolian patients with Parkinson’s Disease
Objective: To investigate the distribution of genetic variants among Mongolian patients with Parkinson’s disease within the framework of the international GP2 project MONPAR study .…Gut Microbiome Metagenomics in Parkinson’s Disease Stratified by the Asian-Prevalent LRRK2 Variants p.G2385R and p.R1628P
Objective: To compare gut microbiome profiles of manifesting LRRK2 p.G2385R or p.R1628P carriers (LRRK2-PD) and idiopathic Parkinson’s disease patients (iPD). Background: Leucine-rich repeat kinase 2…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…The Emerging Landscape of Genotype-Stratified Clinical Trials in Parkinson’s Disease and Atypical Parkinsonian Disorders
Objective: To characterize the landscape of genotype-stratified clinical trials in Parkinson’s disease (PD) and atypical parkinsonian disorders (APD), including therapeutic targets, geographic representation, and trial…Phase 1 Study of BT-267, a potent, selective, brain-penetrant, and oral small molecule inhibitor of LRRK2
Objective: The aim of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BT-267 in healthy adults. Background: Leucine rich repeat kinase…SAA Positivity Rate Amongst Dual LRRK2-GBA1, GBA1 and LRRK2 Carriers with Parkinson’s Disease
Objective: We investigated positivity rate in dual GBA1+LRRK2-PD by comparing GBA1+LRRK2-PD carriers(n=13), GBA1-PD(n=169) and LRRK2-PD(n=175). Background: GBA1 and LRRK2 variants represent the most common genetic…
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