Locus coeruleus degeneration associated with less levodopa responsiveness in Parkinson’s Disease
Objective: We aimed to explore the relationship between LC degeneration and levodopa responsiveness in Parkinson’s Disease (PD) patients in vivo. Background: Widely divergent responsiveness of…LY-487,379 alleviates parkinsonism when administered as monotherapy in the MPTP-lesioned marmoset
Objective: To determine the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation as monotherapy on parkinsonism, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset. Background: We…Influence of Levodopa on Archimedes Spiral Drawings in Idiopathic Parkinson’s Disease
Objective: To study the effects of levodopa on Archimedes spiral drawings by idiopathic Parkinson’s Disease (PD) patients. Background: Handwriting difficulty can develop as an early…Carboplatin, Paclitaxel, and Nivolumab-induced Parkinsonism Responsive to Levodopa
Objective: To present the first reported case of reversible, levodopa sensitive, chemotherapy- induced parkinsonism due to the combination of carboplatin, paclitaxel, and nivolumab. Background: Many case reports describe antineoplastic agents causing reversible parkinsonism, most commonly, cyclophosphamide, cytosine arabinoside, and cyclosporine. To our knowledge, drug-induced parkinsonism related to combination therapy of paclitaxel, carboplatin, and nivolumab has never been…Effect of the mGlu2/3 orthosteric agonist LY-404,039 on abnormal involuntary movements and parkinsonism in the 6-OHDA-lesioned rat
Objective: To assess the effect of LY-404,039 on dyskinesia and parkinsonism in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease (PD). Background: LY-404,039 is an…Humor processing is affected by Parkinson’s disease and levodopa
Objective: This study investigated humor comprehension and appreciation deficits in Parkinson’s disease (PD) as potential non-motor symptoms, and the effect of levodopa on these processes.…Overview of the population of patients with advanced Parkinson’s disease (aPD) initiating therapy with levodopa-carbidopa intestinal gel (LCIG): POMPE-PARK study on French health insurance data (2013-2017)
Objective: To quantify the number of French aPD patients initiating continuous delivery of LCIG from 2013 to 2017 and to describe their demographic, clinical and…LY-487,379 enhances the anti-parkinsonian action of a low dose of L-DOPA in the MPTP-lesioned marmoset
Objective: To investigate the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation on the anti-parkinsonian action of a low dose of…Comparison of gastrointestinal transit times in typical and erratic levodopa-responders in patients with Parkinson’s disease.
Objective: To determine if altered transit time in the various segments of the gastrointestinal (GI) tract relates to the variability of clinical responses and serum…Tinospora Cordifolia protects against Rotenone induced degeneration of dopaminergic neurons in mouse model of Parkinson’s disease
Objective: To explore the neuroprotective mechanisms of T. cordifolia ethanolic extract against Rotenone (ROT)-intoxicated mouse model through proteomics approach. Background: The death of dopaminergic (DAergic)…
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