Dysphagia predicts poor outcome in late-stage Parkinson’s disease
Objective: to evaluate the clinical progression and prognostic factors of a late-stage PD (LSPD) population. Background: Parkinson’s disease (PD) disability milestones emerge in an exponential…Personal KinetiGraph™ Movement Recording System: An Assessment of Utility in a Movement Disorder Clinic
Objective: The objective of this open-label study was to evaluate the clinical utility of the Personal KinetiGraph™ (PKG) Movement Recording System in the care of…Levodopa effect on non-motor symptoms in late stage Parkinson’s disease
Objective: To assess responsiveness of non-motor symptoms (NMS) to Levodopa (L-dopa) and to describe the NMS burden in late stage Parkinson's disease (PD). Moreover, to…Gastric Retention of the Accordion Pill™: Results From MRI Studies With Parkinson’s Disease Patients and Healthy Volunteers
Objective: To determine gastric retention (GR) of the Accordion Pill™ (AP) in patients with Parkinson’s disease (PD) and healthy volunteers. Background: While carbidopa/levodopa (CD/LD) is…L-Dopa responsiveness in early Parkinson’s disease: Results from the United Kingdom Tracking Parkinson’s study
Objective: We wanted to evaluate L-dopa responsiveness in a large cohort of patients with recently diagnosed Parkinson’s disease (PD) using an acute L-dopa challenge test.…High dose of levodopa and Segawa disease
Objective: To analyze the dose-dependent effects of levodopa on the symptoms of the disease in our case. Background: In 1976, Segawa et al. reported dopa-responsive…Effects of L-DOPA on Quantitative Gait Parameters Measured with Wearable Sensors
Objective: To quantify and validate the ability of wearable sensors to detect response to symptomatic medication in Parkinson's Disease (PD). Background: While clinical visual assessment…Intrastriatal Fyn silencing as a gene therapy strategy to manage levodopa induced dyskinesia in a mice model of Parkinson’s disease
Objective: To genetically abrogate Fyn expression to reduce levodopa induced dyskinesia (LID) in the 6-OHDA mice model of Parkinson’s disease (PD), using intrastriatal-injected lentiviral (LV)…Design of a Pharmacokinetics Study with Multiple Doses of Accordion Pill™ Carbidopa/Levodopa in Patients with Parkinson’s disease
Objective: To perform a pharmacokinetic (PK) study of the Accordion Pill™ carbidopa/levodopa (AP-CD/LD) and to determine if multiple doses can provide continuous delivery of LD.…A phase Ib trial studying the safety and tolerability of IRL790 in patients with Parkinson’s disease and levodopa-induced dyskinesia
Objective: The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controlled trial. Background: IRL790…
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