Study protocol for the iMarkHD study in individuals with Huntington’s disease
Objective: To describe the study protocol for the iMarkHD study. Background: Huntington’s disease (HD) is still often defined by the onset of motor symptoms, inversely…Neurite Orientation Dispersion and Density Imaging and Diffusion Kurtosis Imaging in Brainstem Nuclei for Subtypes of Parkinson’s Disease
Objective: We utilized neurite orientation dispersion and density imaging (NODDI) along with diffusion tensor and kurtosis imaging (DTI/DKI) to assess brainstem nuclei in Parkinson’s disease…The role of the glymphatic system on the severity and distribution of alpha-synuclein pathology in alpha-synuclein fibril induced rat model of Parkinson’s disease
Objective: The aim of this study is to investigate the contribution of the glymphatic system to the pathophysiology of Parkinson's disease (PD). Background: Neurotoxicity of…Impaired structural connectivity in Parkinson’s disease with probable RBD
Objective: To characterize structural connectivity through whole-brain network-based statistics and graph theory implementation in treated Parkinson’s disease (PD) patients with probable REM sleep behavior disorder…Post-operative imaging findings in deep brain stimulation
Objective: To study post-operative imaging findings following deep brain stimulation (DBS) and to analyse their association with the patient`s clinical status. Background: DBS is widely…Assessment of novel diffusion MRI metrics of cortical microstructure in the genetic continuum of Parkinson’s disease
Objective: To investigate novel cortical diffusivity metrics in Parkinson’s disease (PD), including both prodromal and established genetic PD, alongside sporadic PD and healthy controls (HC).…White Matter Perivascular Spaces in Parkinson’s Disease are Associated with Decreased Cognition, Interrupted Sleep, and Less Physical Activity
Objective: To determine the association of Perivascular Spaces (PVS) and non-motor features in Parkinson’s disease (PD). Background: PVS are the fluid-filled spaces surrounding blood vessels…Characterization of neuromelanin MRI as a potential Parkinson’s Disease biomarker in a multi-site longitudinal study
Objective: To investigate (1)longitudinal change and (2)cross-sectional vendor differences in neuromelanin MRI in substantia nigra pars compacta(SNpc) in PD patients. Background: Neuromelanin(NM) MRI is a…The role of cortical and subcortical structures in maintaining efficient network topology in Parkinson’s disease
Objective: To assess the relative importance of cortical and subcortical nodes and their connections in maintaining efficient structural connectome topology in Parkinson's disease (PD). Background:…Structural MRI features of glucocerebrosidase (GBA)-associated Parkinson’s disease
Objective: To compare structural differences in brain magnetic resonance imaging (MRI) between Glucocerebrosidase (GBA) mutation carriers with Parkinson’s disease (PD-GBA) vs non-mutation carriers. Background: PD-GBA…
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