Abnormal fractional anisotropy of the tremor network in tremor dominant Parkinson’s disease and Essential tremor plus syndrome
Objective: To evaluate alterations in fractional anisotropy (FA) of the basal ganglia-thalamocortical (BGTC) and cerebello-thalamocortical (CTC) network in tremor dominant Parkinson’s disease (TDPD) and essential…Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in REM Sleep Behavior Disorder
Objective: To determine if there is evidence of cholinergic basal forebrain degeneration, i.e., reduced cholinergic nucleus 4 (Ch4) volume on MRI, in patients with REM…Clinical and electrophysiological validation of a volume of tissue activation model for directional deep brain stimulation leads – the ReCaps study
Objective: Assessing the predictive value of a volume of tissue activation (VTA) model for directional deep brain stimulation (DBS) leads on the response threshold of…Multimodal assessment of nigrostriatal degeneration in de novo Parkinson’s disease
Objective: To study nigrostriatal changes with a multifactorial neuroimaging approach in order to further characterize early abnormalities in Parkinson’s Disease (PD). Background: Imaging techniques allow…Longitudinal Analysis of the Corticospinal Tract in Parkinson’s disease Patients
Objective: To assess longitudinal diffusion tensor imaging differences between PD patients in 8 corticospinal tract segments. Background: Parkinson’s disease (PD) is clinically defined by the presence…Assessment of novel diffusion MRI metrics of cortical microstructure in the genetic continuum of Parkinson’s disease
Objective: To investigate novel cortical diffusivity metrics in Parkinson’s disease (PD), including both prodromal and established genetic PD, alongside sporadic PD and healthy controls (HC).…White Matter Perivascular Spaces in Parkinson’s Disease are Associated with Decreased Cognition, Interrupted Sleep, and Less Physical Activity
Objective: To determine the association of Perivascular Spaces (PVS) and non-motor features in Parkinson’s disease (PD). Background: PVS are the fluid-filled spaces surrounding blood vessels…Characterization of neuromelanin MRI as a potential Parkinson’s Disease biomarker in a multi-site longitudinal study
Objective: To investigate (1)longitudinal change and (2)cross-sectional vendor differences in neuromelanin MRI in substantia nigra pars compacta(SNpc) in PD patients. Background: Neuromelanin(NM) MRI is a…The role of cortical and subcortical structures in maintaining efficient network topology in Parkinson’s disease
Objective: To assess the relative importance of cortical and subcortical nodes and their connections in maintaining efficient structural connectome topology in Parkinson's disease (PD). Background:…Structural MRI features of glucocerebrosidase (GBA)-associated Parkinson’s disease
Objective: To compare structural differences in brain magnetic resonance imaging (MRI) between Glucocerebrosidase (GBA) mutation carriers with Parkinson’s disease (PD-GBA) vs non-mutation carriers. Background: PD-GBA…
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