Arginase2 – a potential mediator in the pathology of the stratum
Objective: To investigate the effects of arginase 2 (Arg2) loss on the striatal mitochondria. Background: Arginase plays a role in the production of various metabolites…Exploring the Neuroprotective Potential of Raloxifene and Fulvestrant Against Haloperidol Induced Parkinson Disease; Insights into GPR30/PI3k/Akt/Nrf2 Signaling Pathways
Objective: To investigate the neuroprotective effect of raloxifene and fulvestrant on behavioral, biochemical, neurochemical, and molecular alterations in a haloperidol-induced animal model of Tardive dyskinesia.To…Solengepras: An Investigational Therapy with Potential Benefits on Functional and Non-Motor Measures in Parkinson’s Disease (PD)
Objective: Solengepras is a GPR6-inhibitor that is being studied as an investigational treatment for Parkinson’s Disease (PD). Background: GPR6 is a novel G-protein-coupled receptor found…The Effect of Modulating Alpha-synuclein Aggregation on Clinical Outcome in the Presence of Standard-of-care Dopaminergic Therapy in Parkinson’s Disease. A Quantitative Systems Pharmacology Approach.
Objective: Understanding the biological link between alpha-synuclein biomarker changes and clinical outcome using computer simulation. Background: A number of disease modifying therapeutic interventions focused on…Role of RNA splicing in Parkinson’s disease
Objective: To identify key molecular perturbations affecting medium spiny neuron functions and their role in the clinical symptoms of Parkinson’s disease (PD). Background: The degeneration…Exploring the Therapeutic Potential of Microglial Modulation in Parkinson’s Disease: A Study on Structural Synaptic Plasticity
Objective: We aim to explore the role of glial cells in Parkinson's disease and assess whether modulating microgliafunction could offer therapeutic benefits. Specifically, we investigate…Tissue-Engineered Nigrostriatal Pathways: An Anatomically-Inspired Model of Synucleinopathy in Human Neurons
Objective: The objectives of this study were (1) to create a human cell-based three-dimensional neural network that recapitulates the discrete somatic and axonal compartments of…Non-apoptotic caspase-3 activation mediates early synaptic dysfunction of indirect pathway neurons in the parkinsonian striatum
Objective: We set out to investigate whether caspase-3 plays a role in the loss of dendritic spines and the concomitant synaptic deficits that develop in…MPTP-induced structural reorganization of neurons in mice Basal Ganglia: Verifying the sequelae of differential toxicity
Objective: To evaluate the changes in the neuronal arborization of the medium spiny neurons of striatum & substantia nigra neurons, in response to MPTP in…Development of novel treatment strategies for SGCE dystonia using patient-derived induced pluripotent stem cells (iPSCs)
Objective: What are the underlying pathological mechanisms of myoclonus dystonia (DYT-SGCE)? Background: Myoclonus dystonia (DYT-SGCE, DYT11) is a combined dystonia characterized by alcohol-sensitive myoclonic-like appearance…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.