Extracellular Neuromelanin Promotes Microglial Reactivity in Parkinson’s Disease
Objective: To investigate the interaction between neuromelanin (NM) and microglia in Parkinsons’s Disease (PD) using human post-mortem midbrain tissue and induced pluripotent stem cell (iPSC)…Microglial Inflammatory Signaling Mediates Neuroimmune Dysregulation And Behavioral Dysfunction in A Parkinson’s Disease Model
Objective: To determine whether M1 microglial signaling via FAM19A3, CHI3L1, and VILIP-1 contributes to neuroinflammation, neuronal degeneration, and behavioral dysfunction in a Parkinson’s disease, and…Mechanistic study of PARP9-mediated mitochondrial transfer in regulating dopaminergic neuronal injury and neuroinflammation in Parkinson’s disease
Objective: To investigate PARP9 expression and localization in PD models, evaluate its effects on dopaminergic neuronal injury and microglial activation, and determine whether PARP9 regulates…Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum
Objective: To evaluate plasma and PBMC biomarkers of neurodegeneration, neuroinflammation, microglial activation, and oxidative stress across clinically defined stages of Parkinson's disease (PD). Background: PD…GBA1 L444P mutation increases susceptibility to neuroinflammation and promotes pro-inflammatory immune responses
Objective: To determine whether the GBA1 L444P mutation increases susceptibility to neuroinflammation and alters immune responses during CNS inflammatory challenge. Background: Mutations in GBA1, which…Differential Microglial Activation and p-Ser129 Alpha-Synuclein Induction by Neurotropic and Non-Neurotropic Influenza A Virus Strains
Objective: To compare the innate immune responses and neurodegenerative marker induction in human microglia following infection with neurotropic vs. non-neurotropic Influenza A virus (IAV) under…Glial interaction with Parkinsonian disorders biomarkers: alpha-synuclein, dopaminergic dysfunction and clinical stages
Objective: We aim to investigated the relationship between glial markers and Parkinson's disease. Background: Neuronal α-Synuclein Disease (NSD) has recently been proposed as a framework for…Microglial Activation and Phenotype in Air Pollution Neurotoxicity: Implications for Parkinson’s Disease
Objective: To evaluate the impact of air pollution on microglial activation and phenotype and determine whether these changes persist following air quality improvement. Background: Epidemiological…The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson’s Disease.
Objective: To evaluate the possible neuroprotective effects of mitochondrial NLRP3 inflammasome inhibition in a 6-hydroxydopamine mouse model of Parkinson's Disease. Background: Overactivation of brain immune…Quercetin hinders Glial Activation to Alleviate the Cadmium Induced Dopaminergic Alteration via TNFα mediated CAMKIIα/ERK activation
Objective: The present study has therefore been carried out identify neuroprotective role of quercetin in alleviating the cadmium induced dopaminergic dysfunctions via glial mediated deactivation…
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