The relationship between MIBG myocardial scintigraphy and clinical factors in multiple system atrophy
Objective: This study aimed to clarified the relationship between the degree of MIBG accumulation and clinical factors in patients with MSA. Background: 123I-MIBG myocardial scintigraphy considered to…Alpha-synuclein and Amyloid beta peptide 1-42 in Parkinson’s disease and parkinsonian plus syndrome cohorts
Objective: To evaluate the serum levels of α-synuclein (α-syn) and Amyloid β 1-42 (Aβ1-42) in the patients of Parkinson’s disease (PD), progressive supranuclear palsy (PSP)…Serum MIR-96-5P and MIR-339-5P as a Potential Biomarker for Multiple System Atrophy and Parkinson’s Disease
Objective: The aim of our study was to to determine if serum mir-96-5p and mir-339-5p can be used as biomarkers for early diagnosis of Parkinson’s…Multiple System Atrophy – perspectives in diagnosis?
Objective: The aim of this study was to study the role of perfusion single photon emission computed tomography (SPECT) in the examination of multiple system…Premature State of Oligodendrocytes Potentially Provides Critical Period for Extracellular Pathological α-Synuclein to Invade Oligodendrocyte Lineage Cells
Objective: Multiple system atrophy (MSA) is pathologically characterized by accumulation of misfolded α-synuclein (α-syn) in oligodendrocytes (OLGs), which is known as glial cytoplasmic inclusions (GCIs).…Multiple system atrophy with predominant striato-nigral degeneration (MSA-P) and TDP-43 pathology: an unusual pathologic variant of MSA
Objective: To report a patient with MSA with concomitant occurrence of TDP-43-labeled and a-synuclein labeled inclusions in oligodendrocytes. Background: The pathologic hallmark in multiple system atrophy…Alpha-synuclein seeding activity in blood samples from synucleinopathy patients
Objective: Utilize a cell-based assay to determine whether a-syn seeding activity can be amplified and detected from blood components from patients with Parkinson’s disease (PD)…Widespread distribution and abundant accumulation of alpha-synuclein oligomers in multiple system atrophy brain
Objective: To examine the distribution of alpha-synuclein (αSyn) oligomers as an early pathological change in multiple system atrophy (MSA) brains. Background: Although severe neuronal loss…The etiologies of chronic progressive cerebellar ataxia in a Korean population
Objective: The etiologies and frequency of cerebellar ataxias vary among countries. Our primary aim was to assess the frequency of each diagnostic group of cerebellar…Apolipoprotein E and multiple system atrophy
Objective: This study evaluated genetic associations of Apolipoprotein E alleles with risk of multiple system atrophy (MSA) and α-synuclein pathology, and also examined whether apolipoprotein…
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