Apolipoprotein E and multiple system atrophy
Objective: This study evaluated genetic associations of Apolipoprotein E alleles with risk of multiple system atrophy (MSA) and α-synuclein pathology, and also examined whether apolipoprotein…Serum fractalkine levels in Parkinson’s disease: Evidence for neuroinflammation
Objective: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra. We measured neuroinflammatory marker fractalkine in…PROMESA: A randomised, double-blind, placebo-controlled trial to evaluate the progression rate of MSA under EGCG supplementation as anti-aggregation-approach
Objective: To evaluate the safety and tolerability of epigallocatechin gallate (EGCG) in high doses and its efficacy to slow down disease progression in patients with…Effects of mannitol treatment in a mice model of multiple system atrophy (MSA)
Objective: The aim of this study was to examine the effect of mannitol treatment in a mice model of MSA. Background: Alpha-synuclein aggregation represents the…Expanding the NINDS Parkinson’s Disease Biomarkers Program – Utilizing a Major Biomarker Resource to Address Atypical Parkinsonisms and Related Conditions
Objective: Expansion of a carefully curated resource for clinical and biosample data to address a critical need for biomarker discovery in Atypical Parkinsonisms and related…Immunological causes of atypical parkinsonism
Objective: To study the clinical and biochemical features of atypical parkinsonism. Evaluate results of the immune-mediated treatment Background: Atypical parkinsonism is a heterogeneous group of…Cerebrospinal fluid levels of cytokines in multiple system atrophy: A cross-sectional study of the atalan msa registry (CMSAR)
Objective: To compare the cerebrospinal fluid (CSF) levels of 38 cytokines in multiple system atrophy (MSA) patients vs. control and Parkinson’s disease (PD) subjects. Background:…Gut Microbiota in Multiple System Atrophy
Objective: To investigate the gut microbiome and metabolome in MSA Background: Experimental models of prion-like cell-to-cell transfer of alpha-synuclein(AS) and its ability to spread from the…Evaluation of mitochondrial dysfunction in fibroblasts and iPSC-derived dopaminergic neurons of patients affected by Multiple System Atrophy
Objective: The aim of the present study is to investigate mitochondrial functioning in fibroblasts and iPSC-derived dopaminergic neurons of patients affected by Multiple System Atrophy…Are a „mathematical brain“ and early childhood adverse events possible risk factors that contribute to Progressive Supranuclear Palsy?
Objective: To evaluate possible risk factors for the development of Progressive Supranuclear Palsy (PSP). Background: Risk factors for the development of neurodegenerative brain disorders are…
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