Natural history and disease progression biomarkers of multiple system atrophy: the ASPIRE-MSA study
Objective: To evaluate multiple system atrophy (MSA) disease progression on a panel of candidate MSA biomarkers pre-selected for their putative involvement in the pathophysiology of…Hypothalamic involvement in Multiple System Atrophy: a clinical and neuroimaging study
Objective: To investigate hypothalamic atrophy and its clinical correlates in Multiple System Atrophy (MSA) through MRI. Background: MSA is characterized by autonomic dysfunction, i.e. orthostatic…Disease progression in multiple system atrophy: the value of clinical cohorts with long follow-up
Objective: To describe MSA progression according to the latent disease continuum and assess the value of long-term follow-up. Background: Although essential for therapeutic development, describing…Exosomal α-synuclein in Multiple system atrophy and parkinson’s disease cause distinct synucleinopathies
Objective: In this study, we investigated the differences in exosomal α-syn between MSA and PD patients. Background: Parkinson's disease (PD) and multiple system atrophy (MSA)…Short-term effect of continuous positive airway pressure in MSA patients with sleep disordered breathing
Objective: SBD are frequent in MSA, mainly represented by inspiratory stridor, obstructive and central sleep apnea/hypopnea syndrome (SAS), or hypopneaimpacting the quality of sleep. A…Brain metabolism associated with clinical feature in patients with multiple system atrophy
Objective: We aim to investigate how structural metabolism of the brain affects survival in patients of multiple system atrophy (MSA). Background: Multiple system atrophy (MSA)…Detection of specific antigens in immune-mediated cerebellar ataxias
Objective: We aimed to clarify biomarkers and pathogenic autoantibodies in cerebellar ataxia, especially multiple system atrophy (MSA) and immune-mediated cerebellar ataxias (IMCAs), by detection of…Neurodegeneration and neuroinflammation for biomarker development in MSA
Objective: To investigate the diagnostic and prognostic value of fluid-based and PET imaging biomarkers related to neurodegeneration and neuroinflammation in Multiple System Atrophy (MSA). Background:…Comorbid neuropathological features in multiple system atrophy
Objective: To elucidate the distribution of comorbid neuropathology in multiple system atrophy (MSA) and its clinical correlation. Background: Multiple protein accumulations are often present in…Cerebrospinal α-synuclein RT-QuIC in pathologically-confirmed Multiple System Atrophy
Objective: To assess the sensitivity of CSF α-synuclein RT-QuIC in pathologically-confirmed MSA. Background: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterised pathologically by…
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