Firing rate and proportion of subthalamic oscillatory neurons increase associated with more advanced Parkinson’s Disease
Objective: To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with…Subcortical involvement in body and mental action processing: an electrophysiological registration study
Objective: The current research project focusses on the electrophysiological registration of semantics (body versus mental action verbs) within the thalamus, subthalamic nucleus (STN) and the…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Medication optimization in Parkinson’s disease patients with ON-state freezing using objective gait assessments
Objective: To determine whether objective gait assessments could guide therapeutic decision making in Parkinson’s disease (PD) patients reporting freezing of gait (FOG) in the levodopa-ON…Listen to your heart: ordinal pattern statistics reveal altered cardiac rhythm dynamics in LRRK2-nonmanifesting carriers
Objective: To assess the complexity of heart rate variability (HRV) dynamics in LRRK2-nonmanifesting carriers compared to healthy individuals. Background: Cardiovascular autonomic dysfunction is an early…Oscillatory Activity in the Nucleus Basalis of Meynert
Objective: Characterize oscillatory activity in and around the nucleus basalis of Meynert (NBM). Background: The NBM is the major source of cholinergic innervation to the…Impaired intracortical inhibition is associated with reduced hand dexterity in Parkinson’s disease patients
Objective: To check whether hand dexterity in Parkinson’s disease (PD) patients is linked with motor cortex excitability and plasticity. Background: Hand dexterity is impaired in…The Pull Test in healthy subjects and Parkinson´s disease: quantitative pull-force measure, postugraphic and electromyographic analysis
Objective: To study and compare in healthy subjects and patients with Parkinson´s disease (PD) the destabilizing force needed to reach the limit of stability (LoS), the displacements of…Intracortical plasticity is preserved in de novo Parkinson’s disease: a tSMS study.
Objective: To test the intracortical plasticity of motor cortex in treatment-naïve (de novo) patients with Parkinson’s disease (PD), by means of transcranial static magnetic field…Beta oscillatory changes during practice and retention of motor skills in healthy subjects and patients with PD
Objective: The objective is to define the relationship between increase in beta oscillatory changes with practice and retention of motor skills in normal healthy subject…
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