Efficient control of dopamine neuron physiology for rescuing disease phenotypes
Objective: Dopamine neurons (DAs) of the substantia nigra degenerate in Parkinson's disease and are disrupted in Huntington's disease. Here we propose single cell computational modeling…Objective gait parameters as a noninvasive biomarker for freezing of gait in Parkinson’s disease patients
Objective: To determine if steady-state gait parameters in Parkinson disease (PD) patients could serve as a predictive biomarker for freezing of gait (FOG). Background: FOG…The AppTUG : a new application for analyzing the Timed Up and Go task in patients with neurological disorders
Objective: To perform an initial validation of a newly developed smartphone-based Timed Up & Go (TUG) application (AppTUG), by comparing its measurements to the stopwatch-measured…Focused ultrasound subthalatomy restores intracortical inhibition in PD
Objective: To test the effects of focused ultrasound subthalatomy on motor cortex excitability in Parkinson’s disease (PD). Background: Short-interval intracortical inhibition (SICI), a GABAAR-mediated inhibition…Prism adaptation and cerebellar inhibition were impaired in essential tremor
Objective: We aimed to reveal cerebellar dysfunction in patients with essential tremor using neurophysiological methods. Background: Cerebellar dysfunction is suggested to contribute to tremor generation.…A new neurophysiological tool for differential diagnosis in tremor syndromes: The Tremor Stability Index
Objective: We present a robust new neurophysiological measure, the Tremor Stability Index (TSI), which can discriminate Parkinson’s disease tremor (PD) and Essential tremor (ET) with…An auditory biomarker for Parkinson’s Disease ?
Objective: In this preliminary study we aimed to investigate the nature of the differences in auditory function between patients with PD (N=25 with Hoehn and…Tremor Characteristics in Essential Tremor and Dystonic Tremor
Objective: To explore the characteristics of tremor in patients with ET and DT by using neurophysiologic measures. Background: Tremor features in patients with essential tremor…Automated DBS Contact Selection using Coherence in Parkinson’s Disease
Objective: To investigate whether subthalamic nucleus (STN)-EMG coherence can be used to predict the most effective deep brain stimulation (DBS) contact. Background: Although DBS is…Tremor in motorneuron disease: central or peripheral origin?
Objective: To investigate whether postural/action tremor in motorneuron disease (MND) has a central origin. Background: MND refers to the whole spectrum of progressive degenerative diseases…
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