Encoding of action plans and confidence in the human basal ganglia-thalamic circuit
Objective: The basal ganglia (BG) are known to play a vital role in action initiation and inhibition, studied with several simple behaviors in multiple species.…Detecting clinical fluctuations in chronic biomarker recordings: experiences with chronic subthalamic peak beta band recordings in a large Parkinson’s disease patient cohort
Objective: Since the understanding of electrophysiological biomarker dynamics during every-day activities is crucial for adaptive deep brain stimulation (aDBS), this study aims to investigate characteristics…Neurophysiological analysis of the posterior subthalamic area in a patient with Holmes’ tremor
Objective: To analyze the neuronal firing patterns in the posterior subthalamic area (PSA) in a Holmes’ tremor (HT) patient who underwent DBS implantation procedure. Background:…Polyneuropathy in Parkinson’s disease: cross-sectional analysis of the Bochum Parkinson Nerve Study cohort
Objective: To describe the prevalence of large-fiber polyneuropathy (PNP) in people with PD and examine differences between subjects with or without PNP. Background: Non-motor symptoms…Pallidal activity as a driving force of choreic movements
Objective: To investigate the mechanisms of neuronal discharges of the globus pallidus which drive choreic movements. Background: Synchronized bursts and the low discharge rates of…Tai Chi training of people with Parkinson’s disease (PD) – neuropsychological and electrophysiological analyses
Objective: To analyze the influence of Tai Chi training on neurological changes, neuropsychology, quality of life (QoL) and EEG in PD patients. Background: Besides pharmacological…People with Parkinson’s Disease present compensatory cortical activity patterns during split-belt treadmill walking, regardless of leg or disease side dominance.
Objective: To study the effects of Parkinson’s Disease (PD) on cortical activity during split-belt (SB) walking compared to tied-belt (TB) walking, and the impact of…Stability of beta oscillations during aDBS in Parkinson’s disease: a methodology for reliable assessment
Objective: In this work, we describe a methodology to assess whether a specific oscillation, considered as biomarker for adaptive DBS (aDBS), is stabilized during stimulation,…Enrollment phase sensing data from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial
Objective: To describe enrollment sensing data from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) trial (NCT04547712). Background: Local field potential (LFP)…The effect of dopaminergic medication on force fluctuation in Parkinson’s disease
Objective: To quantify and compare muscle force variability during isometric dorsiflexion in male patients with Parkinson's Disease (PD), in the ON- versus OFF-medication state. Background:…
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