Novel C-KIT/C-Abl Inhibitor BK40196 Alleviates Neurodegenerative Pathology And Improves Behavioral Performance In A53T Mice
Objective: Here we synthesized a novel c-KIT/c-Abl inhibitor BK40196 and investigated its effects on alpha-synuclein, neuro-inflammation , dopamine and behavior in A53T mice. Background: Inhibition…Comparative Analysis of miR-29a Expression in Optimized Medical Therapy and Intestinal Infusion Therapies in Advanced Parkinson’s Disease
Objective: To compare the relative expression of miR-29a in patients with advanced Parkinson's disease (PD) receiving optimized medical therapy (OMT) versus intestinal infusion therapies—levodopa/carbidopa intestinal…Disease Modifying Potential of a Novel ROCK Inhibitor in Rodent Models of Synucleinopathy
Objective: Evaluate the impact of a novel Rho-associated kinase (ROCK) inhibitor on alpha-synuclein (a-syn) pathology, neuroinflammation, and dopamine neurodegeneration in the AAV-a-syn overexpression and a-syn…Mechanistic Insights of Tamarindus indica in Acrylonitrile-Induced Neurodegeneration
Objective: The study provides an understanding of the nature of the bioactive compounds of Tamarindus indica fruit pulp and their therapeutic potential using in vitro, in…Neuroprotection on the Horizon: Are GLP-1 Receptor Agonists the Next Breakthrough in Parkinson’s Disease?
Objective: This meta-analysis evaluates the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with Parkinson’s disease (PD). Background: Epidemiological studies suggest an increased…Impact of Over-the-counter Cannabidiol Products on Cognition During the Course of Parkinson’s Disease
Objective: To evaluate the association between Cannabidiol (CBD) usage and cognitive performance, measured by The Montreal Cognitive Assessment (MoCA) in people living with Parkinson's Disease…Therapeutic Effect and Mechanism of Targeted Nano-selenium in Mouse Model of Parkinson’s Disease Induced by MPTP
Objective: In the present study, we developed a nanozyme (Se@PB-ACPP) incorporating selenium-loaded Prussian blue (PB) and modified it with an activatable cell-penetrating peptide (ACPP) to…Prodromal Parkinson’s Disease in Agent Orange Exposed US Vietnam Veterans
Objective: 1-Comparing the risk of prodromal PD between AO exposed veterans (AOEV) and non-AO exposed veterans without PD (Controls) in a Veterans Affairs (VA) hospital…GCase and Ganglioside GM1 Interaction in Parkinson’s Disease
Objective: The project aims to further understand the role of the ganglioside GM1 in the relationship between GBA1 mutations and higher α-synuclein levels. Background: Among…PET and Clinical Evidence for Neuroprotective Effects of KM-819 on MSA
Objective: To assess the effect of KM-819 on the progression of multiple system atrophy (MSA). Background: Parkinson’s brain is associated with increased expression of the…
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