MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Neuroprotective agents"

  • 2024 International Congress

    Design, synthesis and pharmacological evaluation of 16-pyridylmethylene derivatives of steroidal oximes as antiparkinsonian agents in MPTP-injected mice.

    R. Singh, R. Bansal (Chandigarh, India)

    Objective: The objective of the present study is focused on the design and synthesis of 16-pyridyl methylene derivatives of steroidal oximes and further their pharmacological…
  • 2024 International Congress

    Exploring the Neuroprotective Potential of Mushroom Extracts in Parkinson’s Disease In-Vitro Models

    FAZ. Dustov, SEO. Seo (Tashkent, Uzbekistan)

    Objective: This study investigates the potential neuroprotective effects of several mushroom extracts in PD in-vitro models. Background: Parkinson's disease, a progressive condition, involves dysfunction or…
  • 2024 International Congress

    TrkB modulator OT-003 reduces dopaminergic cell loss, mitochondrial stress, alpha-synuclein aggregation and motor dysfunction in Parkinson’s disease models.

    T. Pfeiffer, M. Ho, E. Duckworth, L. Tear, Z. Zahariev, L. Khederlarian, A. Plowright (Sevenoaks, United Kingdom)

    Objective: To assess efficacy and potency of our proprietary lead compound OT-003, an orally bioavailable small molecule Tropomyosin receptor kinase B (TrkB) modulator, in preclinical…
  • 2023 International Congress

    Quercetin hinders Glial Activation to Alleviate the Cadmium Induced Dopaminergic Alteration via TNFα mediated CAMKIIα/ERK activation

    R. Shukla, V. Khanna, R. Gupta (bahraich, India)

    Objective: The present study has therefore been carried out identify neuroprotective role of quercetin in alleviating the cadmium induced dopaminergic dysfunctions via glial mediated deactivation…
  • 2023 International Congress

    Effects of a small molecule angiotensin IV analog on Huntington’s disease animal model

    R. Wells, A. Azzam, A. Hiller, M. Sardinia (Portland, USA)

    Objective: The present study was designed to test if N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (AngIV-6a), an angiotensin IV analog, could attenuate 3-nitropropionic acid-induced Huntington’s disease-like symptoms in…
  • 2023 International Congress

    Pharmacological Invivo and invitro potential of resveratrol in experimental rat models of Parkinson’s disease

    R. Kumar, A. Kanojia (Darbhanga, India)

    Objective: Aim of study was to elucidate the pharmacological Invivo and invitro effects and mechanisms of action ofRT in experimental models of PD. Background: The…
  • 2023 International Congress

    Analysis of the therapeutic potential of IkT-148009 in Parkinson’s disease

    M. Werner, R. Rush, T. Kelly, S. Singh, S. Kruger, C. Olanow, A. Mcgarry (Atlanta, USA)

    Objective: To evaluate the therapeutic potential of the selective, brain penetrant c-Abl inhibitor IkT-148009 in mouse models of progressive PD and the safety and tolerability…
  • 2023 International Congress

    Neuroprotective effects of oral consumption of Bifidobacterium lactis and Lactobacillus acidophilus probiotics on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropytide-induced Parkinson’s Disease mouse model

    C. Mo, Y. Qian, Y. Zhang, X. He, Y. Lai, S. Xu, P. Ai, X. Yang, Q. Xiao (Shanghai, China)

    Objective: To explore the effects of probiotics strains Bifidobacterium animalis subsp. lactis (B.lactis) and Lactobacillus acidophilus (L.acidophilus) on the inflammation of gut-brain axis and degeneration…
  • 2023 International Congress

    Potential genetic link between type I diabetes and Parkinson’s disease.

    K. Senkevich, P. Alipour, E. Chernyavskaya, E. Yu, A. Noyce, Z. Gan-Or (Montreal, Canada)

    Objective: To examine whether type 1 diabetes (T1D) is genetically or causally associated with Parkinson’s disease (PD). Background: Previous epidemiological and mendelian randomization studies demonstrated…
  • 2023 International Congress

    Hesperidin ameliorates rotenone-induced Parkinson’s disease in mice via improving neuroinflammation and oxidative stress

    D. Singh (Prayagraj, India)

    Objective: The goal of the present study is to examine the neuroprotective property of hesperidin on rotenone-induced Parkinson's disease in mice. Background: The second most…
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