Effects of conventional and adaptive deep brain stimulation on systemic oxy-Inflammation in Parkinson’s Disease
Objective: This study investigates the impact of conventional (cDBS) and adaptive deep brain stimulation (aDBS) on systemic oxidative stress (OxS) and inflammation in Parkinson’s Disease…Oxidative stress in Progressive Supranuclear Palsy
Objective: The goal of the study is to evaluate the significance of oxidative stress in the examination and pathophysiology of Progressive Supranuclear Palsy (PSP). Additionally,…Neuroprotective Effects of Thymol in MPTP-Induced Parkinson’s Disease Model in Rats: Molecular Docking, Behavioral, Biochemical, and Histological Investigations
Objective: This study aimed to investigate the neuroprotective potential of thymol in an MPTP-induced Parkinson’s disease (PD) model in rats, focusing on its ability to…Neuroprotective Effects of Co-Administered Hesperetin and Resveratrol Nanoparticles on Oxidative Stress and Neurobehavioral Deficits in Parkinson’s Disease
Objective: This study aimed to evaluate the therapeutic potential of solid lipid nanoparticles (SLNs) containing hesperetin (HE-SLN), resveratrol (RE-SLN), and their co-administration (HE-RE-SLN) in combating…Natural compound Protects Dopaminergic Neurons by Targeting Oxidative Stress and Cell Death Pathways in Parkinson’s Disease
Objective: This study aims to evaluate the neuroprotective potential of a natural compound that protects dopaminergic neurons by targeting oxidative stress and cell death pathways…Mechanistic Insights of Tamarindus indica in Acrylonitrile-Induced Neurodegeneration
Objective: The study provides an understanding of the nature of the bioactive compounds of Tamarindus indica fruit pulp and their therapeutic potential using in vitro, in…Anti-Parkinsonian effects of Globimetula cupulata leaf extract and its underlying mechanisms in 6-hydroxydopamine-lesioned rat model
Objective: To evaluate the neuroprotective effects of Globimetula cupulata in a rat model of Parkinson Disease (PD) induced by 6-hydroxydopamine (6-OHDA) injection in the striatum,…Biomarker Panels for Parkinson’s Disease using Multi-Omics Approach: Recent Developments and Future Directions
Objective: The main objective is to identify potential biomarker panels that may represent disease onset, progression, and risk factors for Parkinson's disease (PD). Background: PD…Deferiprone improves striatal dopamine by reducing neuroinflammation and oxidative stress in MPTP-induced mice model of Parkinson’s disease
Objective: This study aimed to investigate the effect of deferiprone on the striatal DA, oxidative stress and neuroinflammation markers as well as motor deficits in…The Neuroprotective Effects of Rolipram, a Selective Phosphodiesterase IV Inhibitor, on Parkinson’s Disease in Rat Models: A Pharmacological Exploration in both In vivo and In vitro Settings
Objective: Our research sought to unravel the pharmacological effects and mechanisms of action of Rolipram through both in vivo and in vitro experimentation in models…
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