Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…Monitoring oxidative stress and progression to cell death: From secretome to blood diagnosis
Objective: To achieve a comprehensive method able to distinguish the secretome changes caused by oxidative stress regulation or induction of cell death, and thus be…Modulation and mechanism for the neuroprotective effects of 17-beta-estradiol: Relevance to depressive symptoms in Parkinson’s disease
Objective: The objective of this study was to investigate neuroprotective potential of 17β estradiol (E2) treatment on the activities of acetylcholinesterase and monoamine oxidase, membrane…Astroglia exert a neuro-protective role in Parkinson’s disease by reducing oxygen stress through dopamine-induced activation of the pentose-phosphate pathway
Objective: Although dopaminergic neurons themselves take up most of the released dopamine (DA), a part of the DA appears to be taken up by astroglia.…Investigating the role of Parkin in mitigating oxidative stress
Objective: We are investigating the ability of Parkin protein to protect cells from oxidative stress (OS) and the mechanisms that underlie this function. We hypothesize…Disruption of circadian rhythm function and anti-oxidation via SIRT1-BMAL1 pathway in 6-OHDA induced Parkinson’s disease model
Objective: Our aim is to investigate whether the altered expression of clock genes is associated with the dysfunction of the anti-oxidative ability in Parkinson's disease.…Evaluation of the role of oxidative stress in Parkinson’s disease and Parkinson plus syndrome
Objective: To evaluate the role of oxidative stress in peripheral blood in patients with Parkinson's disease (PD) and Parkinson plus syndrome (PPS). Background: Slight excess…DJ-1 regulates intracellular signaling in a highly cell type specific manner
Objective: To evaluate a cell type specific action of DJ-1, a PD and cancer associated gene, in intracellular signaling pathways. Background: Understanding the pathophysiology of…
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