Patient-derived GBA1-PARK2 double-mutant cellular models to study the effect of GBA1 as a modifier of familial Parkinson’s disease
Objective: In this study, we propose to decipher the role of GBA1 as a modifier of familial Parkinson’s disease (PD) using double-mutant patient-derived cellular models…How common are the genomic rearrangements among possibly autosomal recessive PD cases in Turkey?
Objective: In this study, we aimed to investigate the frequency and phenotypical features in a subset of early-onset Parkinson’s disease (EO-PD) (age-at-onset ≤45 years) patients due…Parkin (PARK 2) Mutations in Patients with Early-Onset Parkinson’s Disease
Objective: Genetic testing Parkin (PARK 2) gene in patients with young-onset Parkinson's disease in Belarus. Background: The diagnosis of young-onset Parkinson's disease (PD) is the same…Effect of deep brain stimulation on visuospatial impairment in Parkinson’s disease
Objective: We evaluated postoperative change of visuospatial impairment in the patients with Parkinson’s disease (PD) underwent deep brain stimulation (DBS) to assess the impact of…Distinct pattern of striatal dopaminergic depletion in patients with parkin mutation
Objective: As a pilot study, this study was aimed to perform the detailed analysis of the striatal DAT density in patients with early-onset Parkinson's disease…Analysis of relationships between spinal deformity and walking ability in Parkinson’s disease patients
Objective: To determine the impact on walking ability of spinal deformity and imbalance as distinct from movement disorder in Parkinson's disease (PD). Background: Despite a…Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2
Objective: Using neuromelanin (NM)-MRI, we analyzed whether disease severity and MF is associated with the degree of dopaminergic neuronal degeneration in the substantial nigra compacta…Heterozygous PINK1 p.G411S mutation increases risk for Parkinson’s disease (PD)
Objective: To investigate the possible disease-association and pathogenic mechanisms of heterozygous PINK1 mutations from a genetic, functional, and structural perspective. Background: It has been postulated…Mitochondrial Hsp90 inhibitor G-TTP triggers PINK1/parkin-dependent mitochondrial quality control
Objective: To characterize the response of cells treated with Gamitrinib-triphenylphosphonium (G-TTP) a mitochondrial targeted inhibitor of the chaperone Hsp90. Background: Upon dissipation of the mitochondrial…Work-related stress and risk for Parkinson’s disease
Objective: To explore the association between work-related stress (job control and job demands) and the risk for Parkinson's disease (PD). Background: Chronic stress is associated…
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