Digital Speech Biomarkers Reveal Speech Changes in Physiological Aging and Parkinson’s Disease
Objective: This study investigates speech characteristics associated with physiological and pathological aging, using Parkinson’s disease (PD) as a model, with the aim of identifying linguistic…Automated Speech Analysis for the Differentiation of Multiple System Atrophy from Parkinson’s Disease in an English-Speaking Cohort
Objective: The aim of this pilot study was to determine whether automatically extracted speech features, derived from targeted speech tasks, can differentiate Multiple System Atrophy…Cryptococcal Meningitis Presenting with Lower Body Parkinsonism and Generalized Chorea: A Case Report
Objective: To report a case of cryptococcal meningitis in a person living with Human immunodeficiency virus (HIV) presented with lower body parkinsonism and subsequent generalized…Amyloid status as a moderator of the association between physical activity and progression of Parkinson’s disease
Objective: We investigated a modulation effect of amyloid copathology on the influence of regular physical activity on the progression of Parkinson disease (PD). Background: Physical…Evaluation of Polygenic Risk Scores Derived from an Updated Cross-European GWAS for Parkinson’s Disease Prediction in European and Ashkenazi Jewish Populations
Objective: To evaluate whether polygenic risk scores (PRS) derived from a recent genome-wide association study (GWAS) improve Parkinson’s disease (PD) prediction compared with PRS derived…Clinical features of vascular parkinsonism
Objective: To analyze the clinical, neurological, and anamnestic characteristics of patients with vascular parkinsonism. Background: Vascular parkinsonism (VP) remains a significant diagnostic challenge due to…Contribution of blood lipid profile to long-term outcome in idiopathic normal pressure hydrocephalus
Objective: Here, we outlined the blood lipid profile, including derived indices of metabolic dyshomeostasis, in iNPH patients, and investigated relationships with brain MRI-based pathology markers,…R1 from 18PR04.MZ as a Proxy for Cerebral Blood Flow in Degenerative Parkinsonism: Comparison with 15O-H2O PET/CT.
Objective: To evaluate the relationship between R1 from 18PR04.MZ and CBF assessed by 15O-H2O PET/CT in patients with parkinsonian syndromes. Background: 18PR04.MZ is an effective…Association of Glymphatic Flow at Diffusion Tensor Image with Motor Symptoms and Striatal Dopamine Degeneration in Parkinson’s Disease
Objective: This study aimed to investigate the association between the diffusion tensor image (DTI) analysis along the perivascular space (ALPS) index, dopamine transporter (DAT) availability…Delayed-Onset Rapidly Progressive Parkinsonism After BCMA×CD3 Bispecific Antibody Therapy: A Case Report
Objective: To describe a delayed-onset rapidly progressive parkinsonian syndrome with encephalopathy following BCMA×CD3 bispecific antibody therapy. Background: B-cell maturation antigen (BCMA) × CD3 bispecific antibodies…
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