Cerebellar Variant of Progressive Supranuclear Palsy: First Case Report from Peru
Objective: To describethe clinical and neuroimaging features of a patient with the cerebellar variant of Progressive Supranuclear Palsy (PSP-C) Background: Progressive supranuclear palsy (PSP)is a…Differential Oculomotor Patterns in Parkinson’s Disease and Multiple System Atrophy With Predominant Parkinsonism
Objective: To investigate the value of oculomotor function assessment in differentiating Parkinson’s disease (PD) from multiple system atrophy with predominant parkinsonism (MSA-P). Background: PD and MSA-P share…Juvenile-Onset Parkinsonism With Bilateral Striatal Necrosis Associated With a Pathogenic MT-ND3 Mitochondrial Variant
Objective: To report a case of juvenile-onset parkinsonism associated with bilateral striatal necrosis and a pathogenic MT-ND3 mitochondrial DNA variant, emphasizing an atypical mitochondrial phenotype…Exploratory Quantitative Gait Analysis for Differentiating Parkinson’s Disease from Atypical Parkinsonian Syndromes
Objective: To compare quantitative spatiotemporal and plantar pressure gait parameters between patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) using instrumented gait analysis.…Axial parkinsonism after 15 years of pallidal stimulation in generalized dystonia
Objective: To characterize long-term motor outcomes and emergence of parkinsonian symptoms after 15 years of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in isolated…A Novel Genome Editing Strategy for Permanent and Precise Downregulation of α-Synuclein in Parkinson’s Disease
Objective: This work aims to develop and evaluate novel nonviral CRISPR-based genome editing strategies to achieve precise and durable transcriptional modulation of SNCA, enabling controlled…Mirrored-Self Misidentification Expands the Neuropsychiatric Spectrum of Corticobasal Syndrome
Objective: To describe mirrored-self misidentification (MSM) occurring in corticobasal syndrome (CBS) without early dementia Background: CBS is a neurodegenerative syndrome characterized by asymmetric parkinsonism and…Smartphone Video-Based Finger Tapping Analysis Using Machine Learning for Parkinson’s Disease Classification
Objective: To evaluate the accuracy of a machine learning model using smartphone-captured finger tapping videos to distinguish patients with Parkinson's disease (PD) from healthy controls…Baclofen-Induced Worsening of Parkinsonism in a Patient with CADASIL and Brainstem Stroke
Objective: To report baclofen-associated worsening of parkinsonism in a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and recent brainstem infarction,…Magnitude of Non-Motor Symptoms Among People with Parkinson’s Disease in Rural and Urban Tanzania
Objective: We aimed to determine the prevalence of non-motor symptoms in people with Parkinson’s disease. Background: Parkinson’s disease is the second most common neurodegenerative disease…
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