Memantine and 3D gait analysis in patient with Parkinson’s disease: an observer-blind randomized clinical trial
Objective: To examine the efficacy of memantine (20 mg), a non-competitive NMDAR antagonist, in the treatment of gait impairment in PD patients with mild cognitive…Multiple system atrophy with predominant striato-nigral degeneration (MSA-P) and TDP-43 pathology: an unusual pathologic variant of MSA
Objective: To report a patient with MSA with concomitant occurrence of TDP-43-labeled and a-synuclein labeled inclusions in oligodendrocytes. Background: The pathologic hallmark in multiple system atrophy…The Progressive Supranuclear Palsy Functional Disability Scale: Sensitivity to change
Objective: To determine the sensitivity to change within 12 months as well as completion time of the Progressive Supranuclear Palsy Functional Disability Scale (PSPFDS). Background:…Early stage Parkinson’s disease patients with GBA mutation have more severe motor symptoms and difficult to differentiate in routine clinical practice
Objective: The objective of this study is to compare clinical features of early stage of Parkinson’s disease (PD) between with and without positive glucocerebrosidase (GBA)…THOR 201: A Proof-of-Concept Study Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of L-dopa delivered by Impel’s Precision Olfactory Delivery (PODTM) to Parkinson’s Disease Patients in an OFF Episode (in the presence of Dopa Decarboxylase Inhibitor)
Objective: Impel NeuroPharma has developed the patient-friendly, self or caregiver actuatedPrecision Olfactory Delivery (IMPEL PODTM) device to achieve consistent upper nasal cavity drug delivery, rapid…Medical and Device-Guided Therapies and Deep Brain Stimulation in Parkinson’s disease: Experience of a Tertiary Centre from Turkey
Objective: This study is aimed to investigate the clinical and therapeutic data of PD patients who have been evaluated at a dedicated-weekly Movement Disorders Clinic. Details…MRI cortical layer study in patients with Parkinson’s disease in Uzbekistan
Objective: We aimed to establish, using MRI, the presence of differences in the thickness of the cortical layers in patients with early and developed stages…Alpha-synuclein seeding activity in blood samples from synucleinopathy patients
Objective: Utilize a cell-based assay to determine whether a-syn seeding activity can be amplified and detected from blood components from patients with Parkinson’s disease (PD)…Relationship of cognitive processing speed with postural stability in non-demented Parkinson’s disease patients
Objective: To measure in PD patients with normal cognitive screening the clinical and instrumental measures of postural stability (PS) and analyze their relationship with cognitive…The differential role of subthalamic and nigral neurons in gait control in Parkinson´s disease patients
Objective: The aim of the study was to identify and characterize subthalamic (STN) and nigral (SNr) neurons showing gait-related activity changes. 12 Parkinson’s disease (PD)…
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