Exosomes from patients with Parkinson’s disease are pathological in mice
Objective: To verify the hypothesis that serum-derived exosomes from patients with Parkinson’s disease (PD) may serve as risk carriers for inter-neuronal risk transmission, eventually resulting…Applicability of modified definition of Vascular Parkinsonism in patients with Parkinsonism attending outpatient department: A tertiary care hospital-based study in south India
Objective: This study aims to assess the applicability of modified Vascular Parkinsonism (VP) criteria in outpatient department in a tertiary care hospital in south India.…123I-FP-CIT SPECT imaging in early PD patients versus mid and late onset PD: Longitudinal data from the PPMI study
Objective: To determine whether there are longitudinal differences in dopaminergic denervation [as exemplified by signal reduction in 123I-FP-CIT SPECT] in early PD patients versus mid…Case-control study of risk developing parkinsonism in Alzheimer’s disease in relation to hypertension, dyslipidemia, and diabetes in Taiwan
Objective: To clarify the relationship between vascular risk factors and parkinsonism in Alzheimer’s disease Background: This case-control study investigated the associations of a history of…Memantine and 3D gait analysis in patient with Parkinson’s disease: an observer-blind randomized clinical trial
Objective: To examine the efficacy of memantine (20 mg), a non-competitive NMDAR antagonist, in the treatment of gait impairment in PD patients with mild cognitive…Multiple system atrophy with predominant striato-nigral degeneration (MSA-P) and TDP-43 pathology: an unusual pathologic variant of MSA
Objective: To report a patient with MSA with concomitant occurrence of TDP-43-labeled and a-synuclein labeled inclusions in oligodendrocytes. Background: The pathologic hallmark in multiple system atrophy…The Progressive Supranuclear Palsy Functional Disability Scale: Sensitivity to change
Objective: To determine the sensitivity to change within 12 months as well as completion time of the Progressive Supranuclear Palsy Functional Disability Scale (PSPFDS). Background:…Early stage Parkinson’s disease patients with GBA mutation have more severe motor symptoms and difficult to differentiate in routine clinical practice
Objective: The objective of this study is to compare clinical features of early stage of Parkinson’s disease (PD) between with and without positive glucocerebrosidase (GBA)…THOR 201: A Proof-of-Concept Study Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of L-dopa delivered by Impel’s Precision Olfactory Delivery (PODTM) to Parkinson’s Disease Patients in an OFF Episode (in the presence of Dopa Decarboxylase Inhibitor)
Objective: Impel NeuroPharma has developed the patient-friendly, self or caregiver actuatedPrecision Olfactory Delivery (IMPEL PODTM) device to achieve consistent upper nasal cavity drug delivery, rapid…Medical and Device-Guided Therapies and Deep Brain Stimulation in Parkinson’s disease: Experience of a Tertiary Centre from Turkey
Objective: This study is aimed to investigate the clinical and therapeutic data of PD patients who have been evaluated at a dedicated-weekly Movement Disorders Clinic. Details…
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