Genotype influences circuit compensation in Parkinson’s disease
Objective: This study investigates differences in brain network organization in patients with Parkinson’s disease (PD) with genetic risk factors relative to sporadic PD patients and…Challenges in Parkinson’s Disease Diagnosis in a Patient with Ipsilateral Hemimelia
Objective: Our main objective is to demonstrate the challenges involved in the diagnosis of parkinsonism in a patient with transverse failure of formation of the…Stability and reliability of objective measures of speech in Parkinson’s Disease over 12 months
Objective: To describe the stability and reliability of acoustic measures of speech in Parkinson’s Disease (PD) at 3 and 12 months. Background: Speech biomarkers hold…Kufor-Rakeb Syndrome with prominent dystonia and new mutations in ATP13A2 gene in two siblings
Objective: To describe new genetic mutations and unusual clinical findings in two siblings with Kufor Rakeb syndrome, an autosomal recessive etiology of parkinsonism. Background: Kufor-Rakeb…SIRT1/AMPK pathway is involved in neuroprotective effects of resveratrol on MPTP-induced neuron loss
Objective: The present study was carried out to observe the neuroprotective effects of RV on MPTP-induced mouse model of PD, and explore its potential neuroprotective…Frequency of the LRRK2 and GBA mutations in Russian population with Parkinson’s disease
Objective: To estimate the frequency of LRRK2 mutation (G2019S) and GBA mutations (N370S, L444P) and polymorphic variants (E326K, T369M) in PD and controls in the…Substantia Nigra Echogenicity Associated with Clinical Subtypes of Parkinson’s Disease
Objective: We classified Parkinson’s disease (PD) patients into different subtypes and evaluated the correlation between the substantia nigra (SN) echogenicity and disease progression. Background: It…Identifying the neural correlates of doorway freezing in Parkinson’s disease
Objective: We aimed to combine a previously validated virtual reality gait paradigm with functional Magnetic Resonance Imaging (fMRI) to investigate the neural correlates underlying doorway-provoked…Impaired topographic organization in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease
Objective: To investigate the disrupted topographic organization in a cohort of cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease (PDAR), and its potential relationships with…Microstructural Abnormalities in Drug-naïve Parkinson’s Disease with Mild Cognitive Impairment: A Diffusion Tensor Imaging Study
Objective: The aim of this study was to use MR diffusion tensor imaging to investigate the brain microstructural alterations in newly diagnosed drug-naïve Parkinson’s disease…
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