Retinal thickness and microvascular pattern in early Parkinson’s disease.
Objective: To detect changes in retinal thickness and their possible correlates with microvascular pattern in early PD patients as compared to controls. Background: Physiologically, retinal…Protective effects of β-Nicotinamide Adenine Dinucleotide against motor deficits and dopaminergic neuronal damage in a Parkinson’s disease mouse model
Objective: The aim of our study is to explore whether nicotinamide adenine dinucleotide (NAD) replenishment could be beneficial on a 6-hydroxydopamine-induced Parkinson’s disease (PD) mouse…A First in Human Study of PBT434, a Novel Small Molecule Inhibitor of Alpha-Synuclein Aggregation
Objective: To evaluate the safety, tolerability and pharmacokinetics of PBT434 in healthy volunteers. Background: PBT434 is a novel, small molecule inhibitor of alpha-synuclein aggregation. In…Deep mitochondrial sequencing in Parkinson’s disease reveals possible genetic modifiers of reduced penetrance in Parkin/PINK1 mutation carriers
Objective: To discover potential penetrance biomarkers in mitochondrial DNA (mtDNA) for Parkin and PINK1 mutation carriers. Background: Biallelic mutations in Parkin and PINK1 are fully…Preparing enhanced arm swing facilitates gait initiation in Parkinson’s disease: a combined EEG-EMG-IMU study
Objective: Objective: To examine the effect of enhanced arm swing when starting to walk on gait initiation and related brain activity in patients with Parkinson’s…Discriminative power of different olfactory domains in Parkinson’s disease
Objective: The aim of this study was to evaluate which kind of olfactory domain was the best in discriminating PD patients from controls, and to…Development and Validation of the Parkinson’s Disease Medication Adherence Scale (PD- MAS)
Objective: To develop and validate the PD-MAS. Background: Parkinson's disease (PD) is a neurodegenerative disease manifested by motor and non-motor symptoms, controlled with drug, neurosurgical…Motor learning and long duration response to levodopa in Parkinson’s disease.
Objective: To define the role of long-duration response (LDR) in motor learning, evaluating neurophysiological parameters in patients affected by Parkinson’s disease (PD) with and without…Brain neurotransmitters and neuropeptides alternations in Parkinson’s induced mouse models
Objective: Present study aimed to investigate the changes in brain neurotransmitters and neuropetides in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models of PD. Background: Parkinson’s disease (PD), a…Clinical-instrumental algorithm for assessment visuospatial dysfunction in patients with Parkinson’s disease
Objective: To study the features of visual spatial dysfunction (VSD) in patients with Parkinson's disease (PD) using modern clinical-neuropsychological, ophthalmological and neuroimaging methods. Background: Visual…
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