Longitudinal assessment of caregiver strain in Parkinson’s disease
Objective: To examine changes in caregivers and predictors of increased caregiver strain in Parkinson's disease (PD). Background: Caregiver strain can increase with advanced PD. In…Quantifying turning behavior in Parkinson’s disease patients using mobile technology
Objective: To use inertial measurement unit (IMU) data from a mobile device, iPad or iPhone, to quantify PD patients' gait and turning behavior, on and…The role of non-steroidal anti-inflammatory use in symptomatic and asymptomatic LRRK2 G2019S mutation carriers
Objective: The purpose of the current study is to determine if non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of Parkinson's disease (PD) among LRRK2 G2019S…Study on association between physical and genetics role in essential tremor – A case control study
Objective: To elucidate the relationships between physical and genetics parameters in essential tremor patients and controls. Tremor is an involuntary, rhythmic shaking of any part…Integrity of the superior longitudinal fascicle and its relationship with anticipatory postural adjustments in people with Parkinson’s disease and freezing of gait
Objective: To assess the integrity of the Superior Longitudinal Fascicle (SLF) and its relationship with the Anticipatory Postural Adjustments (APAs) of step initiation in people…Clinical aspects of postural instability in Parkinson’s disease
Objective: To identify the clinical features of postural instability by PD patients. Background: Postural instability (PI) to maintain body balance while walking. The causes of…Generation of dopaminergic neurons for studying Parkinson’s disease using patient blood cells
Objective: To study the molecular mechanism of G2385R mutation of LRRK2 gene in PD developing, dopaminergic neurons are derived from patient specific induced pluripotent stem…Alpha synuclein and crystallin expression in human lens in Parkinson’s disease
Objective: To determine the Protein Profile of cataract lenses in Parkinson's disease (PD). Background: Protein accumulation, mainly αB-crystallin, in the lens causes cataract. PD is…APL-130277 is a sublingual film being studied in phase 3 trials to rapidly turn patients ON from OFF episodes by delivering apomorphine via the oral mucosa
Objective: Evaluate if any differences exist in the efficacy of APL-130277 doses to turn a patient with Parkinson's disease (PD) from OFF to fully ON…Intrastriatal injection of ionomycin profoundly changes motor response to L-DOPA and its underlying molecular mechanisms
Objective: We investigated whether intrastriatal injection of ionomycin to hemiParkinsonian rats produced changes in L-DOPA responses including LID and analyzed the effects of ionomycin on…
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