When is the worst period of nocturnal hypokinesia in Parkinson’s disease? A sensor-based analysis
Objective: To quantify the number of turning in bed throughout the night as a determinant of the severity of nocturnal hypokinesia. Background: Nocturnal hypokinesia or…Regional differences in the results of a phase 2b study of tozadenant in Parkinson’s disease patients with motor fluctuations
Objective: To assess how the efficacy of tozadenant differed by region in a randomized, double-blind, placebo-controlled trial of Parkinson's disease patients with motor fluctuations. Background:…Distribution of oscillatory activities in MRI confirmed subthalamic nucleus subregions
Objective: To explore the differences and similarities of oscillatory activity between subregions of the subthalamic nucleus (STN). Background: In Parkinson's disease (PD), treatment driven changes…Minimal impact of “interleaving” on neuromodulation device battery drain when interleave frequency is halved
Objective: To contrast neurostimulator battery decay subsequent to the implementation of interleaving with that prior to interleaving. Background: Neurostimulators permit “interleaving”, which allows different same-lead…Improving parkinsonism in DBS poor-responders by surgical lead revision of subthalamic electrodes
Objective: If subthalamic deep brain stimulation (STN-DBS) results in poor symptom control or adverse side effects at low stimulation threshold surgical lead revision for optimal…A case of thalamic malignant glioma formation in a patient with STN-DBS for Parkinson’s disease
Objective: We present a case of development of malignant glioma (glioblastoma multiforme) in the area adjacent to electrostimulation zone in a patient with chronic STN-DBS,…The score changes of clinical symptom assessment scales for multiple system atrophy in 2-3 years
Objective: To examine the extent of disease progression for multiple system atrophy (MSA) during relatively long duration. Background: The knowledge of MSA natural history is…Frequency of GBA1 and LRRK2 G2019S mutations, and body mass index in Ashkenazi Jews
Objective: To evaluate the frequency and characteristics of parkinsonism and Parkinson's disease (PD) attributable to LRRK2 G2019S and Glucocerebrosidase1 (GBA1) mutations in Ashkenazi Jewish (AJ)…The condition of cerebral hemodynamics in the secondary vascular parkinsonism
Objective: To study influence of narrowing lesion of the main brain arteries to progress of secondary vascular stenosis prognosticate stenosis degree and prevent risk factors…Serum brain-derived neurotrophic factor as an indication of disease state in parkinsonism and RBD
Objective: Evaluation of peripheral concentrations of brain-derived neurotrophic Factor (BDNF) in patients with Parkinsonian disorders and correlation with clinical measurements of disease progression to elucidate…
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