Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Objective: To explore the potential use of alpha-synuclein (α-syn) species as candidate biomarkers for Parkinson's disease (PD). Background: Despite decades of intensive research, to date,…A randomized controlled clinical study to evaluate efficacy, safety and tolerability of SC L-dopa/carbidopa (ND0612H) infusion regimens in fluctuating PD patients
Objective: To evaluate the efficacy, safety & tolerability of continuous subcutaneous infusion regimens of ND0612H. Background: L-dopa remains the most effective PD medication, however oral…Long-term safety of levodopa-carbidopa intestinal gel from an ongoing, open-label, phase 3 continued access to treatment study in advanced Parkinson’s disease patients
Objective: To assess the safety and tolerability of levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension) in advanced Parkinson's disease…Body position during sleep in patients with Parkinson’s disease (PD): A sensor-based analysis
Objective: To identify the body position during sleep in PD patients in comparison to their spouses by using multisite wearable inertial sensors. Background: Nocturnal hypokinesia…STEADY-PD III. A phase 3 study of isradipine as a disease modifying agent in patients with early Parkinson’s disease. Baseline characteristics of the enrolled cohort
Objective: To evaluate the efficacy of isradipine 10 mg daily on PD disability. Background: Isradipine, a dihydropyridine calcium channel antagonist with excellent penetration of the…Deep brain stimulation effect on the quality of life of individuals with Parkinson’s disease
Objective: To identify the perception of QOL in individuals with PD pre and post DBS. Background: The DBS is one type of effective treatment in…Does body mass index influence outcome of deep brain stimulation in Parkinson’s patients?
Objective: To investigate if preoperative body mass index (BMI) can predict functional and quality of life (QOL) outcomes following deep brain stimulation surgery (DBS) in…Effect of bilateral subthalamic nuclei deep brain stimulation on impulse control disorders in PD
Objective: To study the effects of bilateral subthalamic nuclei stimulation on impulse control disorders(ICDs) in Parkinson's disease (PD). Background: Impulse control disorders(ICDs) cause significant morbidity…Assessment of freezing of gait in Parkinson’s disease patients treated with STN-DBS
Objective: To evaluate FOG in patients with PD treated with STN-DBS and to compare sensitivity of different assessments of FOG in this specific group of…Movement disorders after stroke in the third Moroccan level hospital, Marrakech
Objective: The goal of this study is to describe the clinical, paraclinical and evolutive features of patients having suffered from a movement disorder in the…
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