Deep Learning-Enhanced Multimodal MRI for Real-World Differentiation of Parkinsonian Disorders
Objective: To develop and evaluate an integrated, deep learning (DL)-enhanced multimodal MRI classification model combining nigrosome-1 (N1), neuromelanin (NM), free-water DTI (FW-DTI) and morphometry (MORPHO)…Ante-Mortem Motor Speech Profiles in Postmortem Confirmed Atypical Parkinsonisms
Objective: Differences in motor speech profiles may aid in diagnosis of atypical parkinsonisms. This is a retrospective study that characterizes ante-mortem motor speech profiles in postmortem…Parkinsonism in B-Cell Maturation Antigen-Targeting CAR-T Cell Cancer Therapies
Objective: Describe parkinsonism after B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy for treatment of multiple myeloma. Background: BCMA-targeted CART-cell therapy effectively treats…FUS R521S mutation causing levodopa responsive amyotrophic lateral sclerosis-Parkinson’s disease (ALS-PD).
Objective: The coexistence of Parkinson's disease (PD) and ALS is uncommon. This overlap syndrome, characterized by levodopa-responsive parkinsonism in the context of ALS, has been…Clinical Characteristics of Fracture Injury by Falling in Parkinson’s Disease, a Prospective Cohort Study
Objective: To explore the clinical characteristics and risk factors of fracture injury by falling in Parkinson’s disease (PD) based on a longitudinal prospective hospital cohort.…Utility of DaTscan in Children with suspected Juvenile Parkinsonism: A Single-Centre Cohort Study
Objective: To evaluate the utility of DaTscan imaging in a cohort of paediatric patients referred to a tertiary neurology centre (Great Ormond Street Hospital, GOSH).…Automated Closed-Loop DBS Using AI Decoding in Parkinson’s Disease: A Systematic Review and Meta-Analysis of UPDRS-III Improvements in tremor, bradykinesia and Motor Fluctuations.
Objective: We conducted a systematic review and meta-analysis (SRMA) to evaluate the efficacy of adaptive Deep Brain Stimulation (aDBS) compared to conventional Deep Brain Stimulation…A highly specific skin α-synuclein seed amplification assay for screening of synucleionpathies
Objective: To evaluate the performance of a skin α-synuclein seed amplification assay (skin_synSAA) as a screening test using samples from movement disorder subjects with uncertain…Quantifying longitudinal clinical trajectories of disease progression and prognosis in Primary Brain Calcification, the Padua PBC-cohort experience
Objective: To characterize longitudinal progression of motor and neuropsychological symptoms in PBC and to identify predictors of disease prognosis Background: Primary Brain Calcification (PBC) is…Young-Onset Parkinson’s Disease with Coexisting GBA1 Mutation and ATXN3 Repeat Expansion: A Double Hit?
Objective: To report a rare case of young-onset Parkinson’s disease (PD) with a positive family history in which the patient was found to harbor double…
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