Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…Clinical, Neuropathological, and Functional Analysis of the Most Prevalent CSF1R Pathogenic Variant, p. Ile794Thr.
Objective: To characterize the clinical presentation, neuropathological findings, and functional consequences associated with the CSF1R p.Ile794Thr variant. Background: CSF1R-related disorder (CSF1R-RD) is a rare, fatal…Impact of TRPV4 Deletion on Nociception in an Experimental Model of Parkinson’s Disease Non-Motor Symptoms
Objective: This study investigated the role of the TRPV4 receptor in nociceptive regulation using an experimental model of Parkinson’s disease (PD) focused on non-motor manifestations.…Metabolic Brain Pattern and Longitudinal Progression in GBA-Associated Parkinson’s Disease Revealed by 18F-FDG PET/CT
Objective: To characterize the cerebral metabolic pattern of GBA-associated Parkinson’s disease (GBA-PD) using 18F-FDG PET/CT and to compare its longitudinal characteristic with genetically undefined Parkinson’s…Analyzing Perceived Effectiveness of Implemented Recruitment and Retention Strategies for Underrepresented Racial and Ethnic Groups in Parkinson’s Disease Clinical Trials
Objective: To analyze racial and ethnic disparities and to identify perceived effective strategies for patient recruitment and retention at Parkinson Study Group (PSG) sites. Background:…Differences in Lewy body dementia in people from ethnic minorities: a systematic review of epidemiology, diagnosis, clinical features and imaging
Objective: To systematically review evidence on epidemiological and clinical differences in Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson’s disease dementia…Urine-derived neuronal extracellular vesicle α-synuclein seed amplification assay for synucleinopathies: a non-invasive biomarker study
Objective: To investigate whether pathogenic α-synuclein can be detected using real-time quaking-induced conversion (RT-QuIC) in urine-derived neuronal extracellular vesicles (NEVs) as a fully non-invasive biomarker…Cerebral Small Vessel Disease Associated with Clinical Heterogeneity in Vascular Parkinsonism
Objective: This study aims to explore the effect of cerebral small vessel disease (CSVD) on the clinical heterogeneity of vascular Parkinsonism (VP). Background: CSVD has…A Clinical Mapping Framework for Motor Balance Impairment in Welders Projected Against Parkinson Disease Severity Stages
Objective: To determine whether welders exhibit Parkinsonian-like motor balance phenotypes by projecting clinical balance scores into Hoehn and Yahr severity space using a PD-trained predictive…Bidirectional associations between seizures and parkinsonism: a retrospective case series
Objective: Within a single center, describe individuals with parkinsonism who develop seizures and vice versa based on epilepsy and movement disorders evaluation. Background: While neurodegeneration…
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