Discontinuation of Parkinson’s Disease Clinical Studies: A Cross-Sectional Analysis
Objective: This study evaluates the characteristics of clinical studies in Parkinson’s disease to identify factors associated with early discontinuation. Background: Clinical studies in Parkinson’s disease are…Efficacy of Combining Outpatient Palliative Care with Standard Care on Quality of Life and Caregiver Burden in Atypical Parkinsonian Syndrome – A Randomised Controlled Trial
Objective: This study evaluates the effectiveness of structured outpatient palliative care combined with standard care compared to standard care alone at 3 and 6 months…The “Guarda” (Tower) Drawing Test: A Novel Bedside Tool to Quantify Bradykinesia in Parkinson’s Disease
Objective: Quantify Bradykinesia Through Standardized Drawing in PD patients. Background: Bradykinesia is the cardinal symptom in Parkinson's Disease (PD). The slowing and progressive reduction in…Standardized Autonomic and Movement Assessment in Mexican Patients with Undetermined and Degenerative Progressive Parkinsonism: A Single-Center Experience
Objective: We proposed a unified and standard autonomic and movement evaluation to discriminate patients' Parkinsonism related to synucleinopathies from other conditions during a clinical office…Beyond the Spinal Tap: Diagnostic Accuracy of Alpha-Synuclein Seeding Amplification Assays (SAA) in Cutaneous and Ocular Biofluids – A Comparative Diagnostic Accuracy Review
Objective: To evaluate the diagnostic performance of alpha-synuclein (a-syn) seeding amplification assays (SAA) in skin and tear fluid (TF) as non-invasive alternatives to cerebrospinal fluid…Traumatic Brain Injury Exacerbates Parkinsonian Neurodegeneration Through Alpha Synuclein Dysregulation
Objective: This study aimed to determine whether repetitive mild traumatic brain injury exacerbates Parkinsonian neurodegeneration and promotes alpha synuclein pathology in an experimental model. Background:…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…Real-World Clinical Outcomes of Adaptive versus Continuous Deep Brain Stimulation in Early-Stage Parkinson’s Disease: A Systematic Review and Meta-Analysis of 2024-2025 Trials
Objective: To evaluate the comparative efficacy, safety, and energy efficiency of adaptive deep brain stimulation (aDBS) versus continuous deep brain stimulation (cDBS) in Parkinson’s disease…Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…Clinical, Neuropathological, and Functional Analysis of the Most Prevalent CSF1R Pathogenic Variant, p. Ile794Thr.
Objective: To characterize the clinical presentation, neuropathological findings, and functional consequences associated with the CSF1R p.Ile794Thr variant. Background: CSF1R-related disorder (CSF1R-RD) is a rare, fatal…
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